Increasing in Chewing Number Reduces Energy Intake in Healthy Weight and Overweight Young Adults

NCT03342313 | Completed DMC

• 1 other identifier: Chewing and energy intake
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

A randomized cross-over design aims to investigate chewing activities between healthy vs. overweight and determine effects chewing times on energy intake and postprandial plasma glucose and insulin. Forty-one participants were allocated into lean and overweight groups according to BMI. Phase I, Bite size (g/bite), bite rate (bites/min), chewing frequency (chews/min), and chews (chews/g food) were recorded after a sandwich breakfast. Phase II, gram of sandwich eaten ad libitum after 15 and 50 chew per bite (number from phase I) were recorded. Postprandial plasma glucose and insulin were examined at 0 (baseline), 30, 60, 90, 120 and 180 min.

Conditions

Mastication

Outcome Measures

Primary Outcomes (1)

• chewing times per bite

  chewing times per bite

  2 months

Secondary Outcomes (4)

• energy intake

  2 months

• hunger, satiety, appetite

  2 months

• postprandial plasma glucose

  at 0, 30, 60, 90, 120 and 180 min after eating

• postprandial plasma insulin

  at 0, 30, 60, 90, 120 and 180 min after eating

Study Arms (2)

healthy weight

EXPERIMENTAL

BMI (kg/m2) ≥ 18.5 and \< 23

Other: Food - Sandwich

Overweight

EXPERIMENTAL

BMI (kg/m2) ≥23 chewing 15 times and 50 times per bite

Other: Food - Sandwich

Interventions

Food - Sandwich OTHER

Sandwich as a breakfast for testing chewing activities.

Overweight; healthy weight

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• non-smoking
• eating breakfast regularly
• not allergic to any food
• no eating disorders
• weight stable over the past 3 months

You may not qualify if:

• have dental problem
• taking any medications or dietary supplements that may confound any study indicators

Sponsors & Collaborators

• Chulalongkorn University: lead

Study Sites (1)

Suwimol Sapwarobol

Bangkok, 10330, Thailand

Location

Related Publications (1)

• Li J, Zhang N, Hu L, Li Z, Li R, Li C, Wang S. Improvement in chewing activity reduces energy intake in one meal and modulates plasma gut hormone concentrations in obese and lean young Chinese men. Am J Clin Nutr. 2011 Sep;94(3):709-16. doi: 10.3945/ajcn.111.015164. Epub 2011 Jul 20.

  PMID: 21775556 BACKGROUND

Study Officials

• suwimol sapwarobol

  Chulalongkorn University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Randomized cross-over design

Study Record Dates

• First Submitted: November 10, 2017
• First Posted: November 14, 2017
• Study Start: March 15, 2015
• Primary Completion: August 18, 2015
• Study Completion: February 4, 2016
• Last Updated: November 14, 2017

Record last verified: 2017-11

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)