Trials Sponsors Conditions Drugs Pricing

Conditions

Carbon Monoxide Poisoning Environmental Exposure

Keywords

carbon monoxide toxicityhigh flow nasal cannulaemergency department

Outcome Measures

Primary Outcomes (1)

Half life of COHb
Half life of COHb levels (%) under the high flow nasal oxygen therapy. Elimination rate of COHb will be determined in every 10 minutes according to venous blood gas COHb level.
between 20 and 120 minutes

Secondary Outcomes (4)

Adverse Events
between 0 and 120 minutes
Device Comfort
Between 0 and 120 minutes
Flow Rate Tolerability
Between 0 and 120 minutes
Flow Temperature Tolerability
Between 0 and 120 minutes.

Study Arms (1)

HFNC therapy

EXPERIMENTAL

Fisher\&Paykel AIRVO™ 2 High Flow Nasal Cannula Therapy will be implemented to CO-poisoned patients. Oxygen flow rate will be started 60 L/min and be decreased as the patient has requested.

Device: Fisher&Paykel AIRVO™ 2 High Flow Nasal Cannula Therapy

Interventions

Fisher&Paykel AIRVO™ 2 High Flow Nasal Cannula TherapyDevice

A high flow nasal cannula will be implemented to the CO-poisoned patients. In the meantime, intravenous access and cardiac monitorization will have been establishing. When the high flow nasal cannula becomes ready, the first venous blood sample will be taken and the treatment will be started without any delay. The gas flow rate will be started at the rate of 30 liters per minute and will be increased to the max flow rate which patient can tolerate and FiO2 of 1.0. If the first COHb level is lesser than 10%, the patient will be excluded and will receive standard emergency care. The blood sample will be drawn from existing IV access every 10 minutes until the COHb levels become %50 or lesser of the initial level. Once the COHb level becomes 50% of initial measurement, following blood samples will be taken in every 30 minutes.

HFNC therapy

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

The patients who are admitted to the emergency department with CO poisoning with a CoHB level of \>10%.
The patients who accept to participate in the study.

You may not qualify if:

Sponsors & Collaborators

Kocaeli University
Otherlead

Study Sites (1)

Kocaeli University Medical Faculty

Kocaeli, Izmit, 41300, Turkey (Türkiye)

MeSH Terms

Conditions

Carbon Monoxide PoisoningEmergencies

Condition Hierarchy (Ancestors)

Gas PoisoningPoisoningChemically-Induced DisordersDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

Elif Yaka, Assoc. Prof.
Kocaeli University
STUDY CHAIR
İbrahim U Özturan
Kocaeli University
PRINCIPAL INVESTIGATOR

Enrollment

35 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principle Investigator, MD

Study Record Dates

First Submitted

October 28, 2017

First Posted

November 14, 2017

Study Start

March 1, 2017

Actual (reported)

Utility of High Flow Nasal Cannula in CO Toxicity

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (1)

HFNC therapy

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (1)

HFNC therapy

Interventions

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Source record

Locations