NCT03339609

Brief Summary

Nowadays there is a growing interest towards non-invasive assessment of urinary dysfunctions in clinical practice. The tendency to use uroflowmetry as a first-line screening tool is based on the inexpensiveness, time efficiency, comfort of the patient, etc. However, it is stated that uroflowmetry as a stand-alone study lacks the potential to make an accurate diagnosis. In regard to this, the International Continence Society indicated that the addition of pelvic floor electromyography might increase the accuracy of this assessment. Despite this recommendation, uroflowmetry in combination with electromyography has not been conducted in a healthy population. The initial objective of this study was to examine whether adding electromyography to standard uroflowmetry in a healthy paediatric population would change the representation of parameters, especially of voiding patterns. In addition, the influence of several factors on uroflow parameters was analysed to complement current literature.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
83

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Sep 2014

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2014

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2017

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2017

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

November 6, 2017

Completed
7 days until next milestone

First Posted

Study publicly available on registry

November 13, 2017

Completed
Last Updated

November 13, 2017

Status Verified

November 1, 2017

Enrollment Period

2.7 years

First QC Date

November 6, 2017

Last Update Submit

November 9, 2017

Conditions

Outcome Measures

Primary Outcomes (2)

  • Uroflow curve pattern - Clinical assessment

    Interpretation by pediatric urologist

    2017

  • Uroflow curve pattern - Mathematical assessment

    Interpretation using Flow index methodology

    2017

Secondary Outcomes (4)

  • Maximal flow

    2017

  • post-void residual urine

    2017

  • voiding time

    2017

  • voided volume

    2017

Study Arms (2)

Immediate uroflow/EMG testing

Participants performed two direct repetitions of uroflowmetry in combination with EMG.

Diagnostic Test: Uroflow/EMGDiagnostic Test: US

uroflow measurement beforehand

Participants performed a preceding measurement of isolated uroflowmetry, followed by two randomized measurements of either isolated uroflowmetry or uroflowmetry with EMG.

Diagnostic Test: UroflowDiagnostic Test: Uroflow/EMGDiagnostic Test: US

Interventions

UroflowDIAGNOSTIC_TEST

Isolated uroflow measurement

uroflow measurement beforehand
Uroflow/EMGDIAGNOSTIC_TEST

Uroflow measurement with superficial EMG testing of the pelvic floor

Immediate uroflow/EMG testinguroflow measurement beforehand
USDIAGNOSTIC_TEST

Ultrasound of post void residual urine

Immediate uroflow/EMG testinguroflow measurement beforehand

Eligibility Criteria

Age5 Years - 12 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)
Sampling MethodNon-Probability Sample
Study Population

continent children with normal development: community sample

You may qualify if:

  • Normal development

You may not qualify if:

  • (Recurrent) urinary tract infections
  • LUTS which interfered with daily life
  • Fecal incontinence
  • History of genitourinary or renal surgery
  • Medication for incontinence during the last 3 months
  • Pelvic reeducation during the last 6 months
  • Neurologic problems influencing continence

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital

Ghent, Belgium

Location

MeSH Terms

Conditions

Lower Urinary Tract SymptomsUrologic Diseases

Condition Hierarchy (Ancestors)

Urological ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 6, 2017

First Posted

November 13, 2017

Study Start

September 1, 2014

Primary Completion

May 1, 2017

Study Completion

June 1, 2017

Last Updated

November 13, 2017

Record last verified: 2017-11

Data Sharing

IPD Sharing
Will not share

Locations