Prevalence of Graves Disease in Patients With Ulcerative Colitis
1 other identifier
observational
95
0 countries
N/A
Brief Summary
Graves disease in ulcerative colitis: The connection between Graves disease and Inflammatory bowel disease is well known in the literature, but thyroid disorders have not been considered extra-intestinal manifestations of ulcerative colitis. In most cases, the diagnosis of thyroid disease has preceded that of Inflammatory bowel disease. Early studies have suggested a relationship between thyroid abnormalities and ulcerative colitis . But it is still uncertain whether the coexistence of Grave's and ulcerative colitis diseases is due to a specific reason or a coincidence.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Nov 2017
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 24, 2017
CompletedFirst Posted
Study publicly available on registry
October 27, 2017
CompletedStudy Start
First participant enrolled
November 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2019
CompletedOctober 27, 2017
October 1, 2017
11 months
October 24, 2017
October 26, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Percentage of patients with graves disease in ulcerative colitis
By use of thyroid antibodies and thyroid sonography
In 2 days
Study Arms (2)
Study group
Patients with ulcerative colitis Interventions to be administered: Thyroid antibodies and Thyroid sonography
Control group
normal control subjects selected from general population at random Interventions to be administered: Thyroid antibodies and Thyroid sonography
Interventions
Thyroid antibodies: Antithyroperoxidase(Anti-TPO), Anti-thyroglobulin (anti-TG) to detect graves disease in study and control groups
Thyroid sonography to detect anatomical changes in thyroid
Eligibility Criteria
seventy five patients who are diagnosed with ulcerative colitis who were admitted to Internal medicine department and who attend outpatient clinics in Assuit University Hospital will be involved in this study compared with 20 normal control subjects selected from general population at random
You may qualify if:
- \. seventy five patients who are diagnosed with ulcerative colitis who were admitted to Internal medicine department and who attend outpatient clinics in Assiut University Hospital will be involved in this study
You may not qualify if:
- Patients with diabetes mellitus.
- patients with a diagnosis of other than ulcerative colitis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Shizuma T. Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review. Biomed Res Int. 2016;2016:5187061. doi: 10.1155/2016/5187061. Epub 2016 Mar 3.
PMID: 27042663BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Alaa K Hussein, MD
Assiut University,Faculty Of medicine
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principal investigator
Study Record Dates
First Submitted
October 24, 2017
First Posted
October 27, 2017
Study Start
November 1, 2017
Primary Completion
October 1, 2018
Study Completion
February 28, 2019
Last Updated
October 27, 2017
Record last verified: 2017-10
Data Sharing
- IPD Sharing
- Will not share