Sympathetic-parasympathetic Ratio of Our Gaze

NCT03322904 | Completed

• 1 other identifier: 09.03.2016/1100
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

ABSTRACT BACKGROUND The existence of the retinohypothalamic pathway suggests that light may influence autonomic outflow activity. The objective of this study was to examine the correlation between the estimated iris muscle sympathetic-parasympathetic area (IRIS) ratio and the sympathetic-parasympathetic ratio (low frequency \[LF\]/high frequency \[HF\] ratio). METHODS The study population consisted of 200 females and 200 males (mean age, 32.4 ± 7.1 years). The IRIS ratio was determined from digital photographs of the iris in a computer setting. The LF/HF ratio was determined from records of heart rate variability obtained using a Holter implementation.

Conditions

Autonomic Nervous System Diseases

Keywords

iris collarette; autonomous nervous system

Outcome Measures

Primary Outcomes (1)

• Correlation between iris ratio and LF/HF ratio

  we have conducted with 400 healthly subjects iris muscle ratio associated with heart rate variability and it is demonstrated cardiac autonomic function. Iris muscle ratio can also be used in diseases accompanied by cardiac autonomic dysfunction.Correlation between pupil diameter and heart rate variability have also been investigated in some diseases where autonomic nervous system disorders are coincident. In Parkinson's disease (PD) is accompanied by autonomic nervous system dysfunction with neurodegenerative changes.. Jain et al. demonstrate simultaneous autonomic nervous system dysfunction in both pupillary diameter and in cardiac system via heart rate variability in PD Similarly, it has been shown that pupil functions in schizophrenia, which have previously been shown to be accompanied by cardiac autonomic dysfunction, may be proportional to the severity of the schizophrenia

  11months

Interventions

iris photography DIAGNOSTIC_TEST

The LF (0.04-0.15 Hz) and HF (0.16-0.4 Hz) ratings were recorded for 24 hours (day and night average) by Holter recording system Photographs of both irises of the healthy volunteers were taken . An image software program was used to draw circular limits over the iris exterior circle (IEC), coloretta circle (CC), and pupil circle (PC) on digital photographs. The areas between the circles were measured. The likelihood that the IRIS ratio was equal to the LF/HF ratio was calculated using the formula \[IEC-PC¬\] - \[CC-PC\] / \[CC-PC\].

Also known as: holter implementation

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 400 healthy volunteers (200 males and 200 females) with brown eyes were included in the study.

You may qualify if:

• We enrolled apparently healthy subjects

You may not qualify if:

• History of diabetes mellitus, hypertension, coronary artery disease, heart failure, cigarette smoking, eye disease, psychological illness, or drug therapy affecting the ANS

Sponsors & Collaborators

• Kecioren Education and Training Hospital: lead

Study Sites (1)

Şahbender Koç

Ankara, 06400, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Autonomic Nervous System Diseases

Condition Hierarchy (Ancestors)

Nervous System Diseases

Study Officials

• Zuhal Koç, specialist

  Saglik Bilimleri Universitesi

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cardıologıst

Study Record Dates

• First Submitted: October 10, 2017
• First Posted: October 26, 2017
• Study Start: March 10, 2016
• Primary Completion: March 5, 2017
• Study Completion: March 5, 2017
• Last Updated: October 26, 2017

Record last verified: 2017-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)