Effect of Clomiphene Citrate on Uterine Blood Fow in Women With Unexplained Delayed Conception
1 other identifier
observational
50
1 country
1
Brief Summary
In a prospective observational study at a university teaching hospital, blood flow indices and serum hormone levels were compared between spontaneous and stimulated cycles in the same group of 50 patients with unexplained delayed conception.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2014
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
October 30, 2016
CompletedFirst Submitted
Initial submission to the registry
October 24, 2017
CompletedFirst Posted
Study publicly available on registry
October 26, 2017
CompletedOctober 27, 2017
October 1, 2017
2 years
October 24, 2017
October 26, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Flow index of the endometrial region
Flow index of the endometrial region was measured by a researcher
Day 22 to 24 of the menstrual cycle
Secondary Outcomes (5)
Vascularization index of the endometrial region
Day 22 to 24 of the menstrual cycle
Vascularization flow index of the endometrial region
Day 22 to 24 of the menstrual cycle
Vascularization flow index of the sub-endometrial region
Day 22 to 24 of the menstrual cycle
Flow index of the sub-endometrial region
Day 22 to 24 of the menstrual cycle
Vascularization index of the sub-endometrial region
Day 22 to 24 of the menstrual cycle
Interventions
The mid-luteal endometrial thickness and volume, uterine vascularization indices of uterine artery pulsatility index and resistance index, endometrial and subendometrial vascularization index, flow index, and vascularization flow index, and serum estradiol and progesterone levels were calculated in spontaneous then stimulated cycles in the same group of infertile patients
Eligibility Criteria
Patients who had unexplained infertility
You may qualify if:
- Unexplained infertility
- Body mass index less than 30
- Regular menstruation
- Normal pelvic examination and ultrasonography
You may not qualify if:
- History of pelvic operations including cesarean section
- History of pelvic inflammatory disease
- Endometriosis
- Pelvic pathology including uterine fibroids
- General disease or medication that could potentially affect pelvic blood flow
- Smoking
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Study Sites (1)
Department of Obstetrics and Gynecology, Kasr Al-Ainy hospital, Cairo University
Cairo, Greater Cairo, 11956, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eman Omran, M.D.
Cairo University
Study Design
- Study Type
- observational
- Observational Model
- CASE CROSSOVER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principal investigator
Study Record Dates
First Submitted
October 24, 2017
First Posted
October 26, 2017
Study Start
October 1, 2014
Primary Completion
October 1, 2016
Study Completion
October 30, 2016
Last Updated
October 27, 2017
Record last verified: 2017-10