A Comparison of Clinical Outcomes of Warmed Embryo Vitrified at 2PN Stage and Fresh Embryo Transfers
Chung Shan Medical University Hospital
1 other identifier
observational
500
1 country
1
Brief Summary
The aim of this study was to compare the clinical outcomes between fresh embryo and frozen embryo transfer in in vitro fertilization (IVF). All frozen embryo was vitrified at pronuclear stage (2PN) and cultured to cleavage embryos for transfer. This is a retrospective study. All IVF cycles were included in this study and further divided into fresh and frozen embryo transfer groups. The collection data including: stimulation protocols, medicines, blood test results, pregnancy test and all clinical data. The primary outcome is pregnancy rate and secondary outcome is implantation rate.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2017
CompletedFirst Submitted
Initial submission to the registry
October 12, 2017
CompletedFirst Posted
Study publicly available on registry
October 23, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2018
CompletedOctober 23, 2017
October 1, 2017
12 months
October 12, 2017
October 20, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
pregnancy rate
HCG test
HCG test at day 15 after embryo transfer or day 18 after oocyte pick up
Study Arms (2)
fresh embryo transfer
patients with fresh day 3 embryo transfer after oocyte pick up, the hormone including FSH, LH, E2 and progesterone was test before embryo transfer for analysis. The clinical outcomes including implantation and pregnancy were checked and recorded.
frozen embryo transfer
freeze-all embryo was performed after oocyte fertilization, the hormone including FSH, LH, E2 and progesterone was test before oocyte pick up and embryo transfer for analysis. vitrification of pronuclear stage embryo (zygote) and frozen embryo transfer
Interventions
according progesterone level to decide fresh or frozen embryo transfer
according day 3 embryo to decide fresh or frozen embryo transfer
Eligibility Criteria
all patients underwent in vitro fertilization protocols in Lee Women's Hospital
You may qualify if:
- all patients with in vitro fertilization protocols
You may not qualify if:
- none
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chung Shan Medical University Hospital
Taichung, 40201, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Maw-Shang Lee, Phd
Lee Women's Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of The Institutional Review Board
Study Record Dates
First Submitted
October 12, 2017
First Posted
October 23, 2017
Study Start
May 1, 2017
Primary Completion
April 30, 2018
Study Completion
April 30, 2018
Last Updated
October 23, 2017
Record last verified: 2017-10