Neuropathic Pain in Children: Multimodal Assessment and Diagnosis

NCT03312881 | Completed

• 1 other identifier: 17NC03
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Some children experience chronic pain that is related to damage or diseases that affect the nerves that send pain signals. This is known as neuropathic pain. This is not well understood and can be difficult to diagnose. It can often produce unusual feelings such as sensitivity of the skin to light touch. Neuropathic pain is often severe and difficult to treat, and can affect quality of life for the child and family. This study aims to better characterise the symptoms and signs, and impact of neuropathic pain in children.

Conditions

Neuropathic Pain; Child, Only

Keywords

pain; neuropathic; children; QST

Outcome Measures

Primary Outcomes (1)

• Self-Report Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) questionnaire

  Sensitivity and specificity of a neuropathic screening tool in children; includes 5 questions related to symptoms and pain descriptors and 2 related to examination

  3 years

Secondary Outcomes (8)

• Paediatric Quality of Life Inventory (Child and Parent report)

  3 years

• Pain Catastrophizing Scale (Child and Parent versions)

  3 years

• Pain Coping Questionnaire

  3 years

• Adolescent Sleep-Wake Scale-Revised

  3 years

• Paediatric Index of Emotional Distress

  3 years

Study Arms (2)

neuropathic pain

Children with clinical diagnosis of neuropathic pain. Interventions: patient reported outcome measures, quantitative sensory testing, neuroimaging

Diagnostic Test: quantitative sensory testing; Diagnostic Test: neuroimaging; Other: Patient Reported Outcome Measures

non-neuropathic pain

Children with clinical diagnosis of non-neuropathic pain. Interventions: patient reported outcome measures

Other: Patient Reported Outcome Measures

Interventions

quantitative sensory testing DIAGNOSTIC_TEST

multiple modality testing of generalized and localized changes in somatosensory perception

neuropathic pain

neuroimaging DIAGNOSTIC_TEST

magnetic resonance imaging (MRI)

neuropathic pain

Patient Reported Outcome Measures OTHER

neuropathic pain screening tool; validated questionnaires

neuropathic pain; non-neuropathic pain

Eligibility Criteria

• Age: 10 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

This study will recruit children and adolescents aged 10-18 years referred to the Great Ormond Street Hospital Pain Service who are clinically diagnosed as having neuropathic pain.

You may qualify if:

• children with a clinical diagnosis of chronic neuropathic pain for the full protocol
• children with a clinical diagnosis of non-neuropathic origin for S-LANSS validation and questionnaires
• children aged 10-18 years

You may not qualify if:

• significant impairment of comprehension (less than school level for 10 year old) that will limit understanding of sensory testing instructions
• inadequate english language skills as questionnaires are validated in English and sensory testing instructions can only be delivered by the Investigators in English For brain imaging, patients will be excluded if they have
• significant medical illness or other (non-neuropathic) neurological disease
• pregnancy
• magnetic implants of any type.

Sponsors & Collaborators

• Institute of Child Health: lead

Study Sites (1)

IChildHealth

London, WC1N 1EH, United Kingdom

Location

Related Publications (2)

• Walker SM, Peters J, Verriotis M, Farag F, Jay MA, Howard RF. Sensitivity and Specificity of a Neuropathic Screening Tool (Self-Report Leeds Assessment of Neuropathic Symptoms and Signs, S-LANSS) in Adolescents With Moderate-Severe Chronic Pain. J Pain. 2024 Feb;25(2):451-465. doi: 10.1016/j.jpain.2023.09.006. Epub 2023 Sep 21.

  PMID: 37741521 DERIVED

• Verriotis M, Peters J, Sorger C, Walker SM. Phenotyping peripheral neuropathic pain in male and female adolescents: pain descriptors, somatosensory profiles, conditioned pain modulation, and child-parent reported disability. Pain. 2021 Jun 1;162(6):1732-1748. doi: 10.1097/j.pain.0000000000002172.

  PMID: 33394878 DERIVED

MeSH Terms

Conditions

Neuralgia; Pain

Interventions

Neuroimaging; Patient Reported Outcome Measures

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Investigative Techniques; Health Care Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Health Services Research; Health Planning; Health Care Economics and Organizations; Patient Outcome Assessment; Outcome Assessment, Health Care; Outcome and Process Assessment, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation; Health Care Evaluation Mechanisms; Public Health; Environment and Public Health

Study Officials

• Suellen M Wallker, MBBS PhD

  UCL GOS Institute of Child Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 27, 2017
• First Posted: October 18, 2017
• Study Start: September 1, 2017
• Primary Completion: July 31, 2021
• Study Completion: December 31, 2021
• Last Updated: February 2, 2022

Record last verified: 2022-01

Locations

GB (1)