Relationship Between Metabolic Profile and Clinical Phenotype in Chronic Obstructive Pulmonary Disease

NCT03310177 | Completed

• 1 other identifier: Metabolomcs-HB
• Study Type: observational
• Target: 167
• Locations: 1 country
• Sites: 1

Brief Summary

Despite the high prevalence of chronic obstructive pulmonary disease (COPD), there continues to be a large gap in our understanding of disease pathogenesis and mechanisms accounting for large variability in disease phenotype. Untargeted metabolomics is an ideal approach to uncover the metabolic basis of disease, as well as discover unique drug target opportunities aimed at these nodal metabolic drivers of disease. There are very limited data from metabolomics studies from plasma/serum and exhaled breath condensate that suggest certain metabolic pathways or metabolites might predict the presence and/or severity of COPD phenotypes. Here, the investigators hope to generate comprehensive, compartment specific (blood and lung) metabolite profiles that will be correlated with various clinical phenotypes of COPD, using a complementary approach of untargeted nuclear magnetic resonance (NMR) and liquid chromatography (LC)- mass spectroscopy (MS) -based metabolomics.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic Obstructive Pulmonary Disease; Metabolomics

Outcome Measures

Primary Outcomes (1)

• Metabolites that can predict the progress of lung function

  The study is aimed to investigate the relationship between the metabolites and the progress of lung function in COPD

  3 months

Secondary Outcomes (2)

• Metabolites that can predict the severity of emphysema

  3 months

• Metabolites that are associated with inflammatory mediators

  3 months

Study Arms (2)

COPD

The smokers who are diagnosed as chronic obstructive pulmonary disease according to GOLD guideline.

healthy control

The healthy controls without chronic obstructive pulmonary disease

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: male
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Clinically stable patients with COPD and controls without COPD are enrolled.

You may qualify if:

• males aged 40-80;
• diagnosed with COPD according to the GOLD guidelines;
• clinically stable patients without medication changes or exacerbation in two months;
• smoking history of more than 10 pack years

You may not qualify if:

• diagnosed with unstable cardiovascular diseases, significant renal or hepatic dysfunction or mental incompetence;
• diagnosed with asthma, active pulmonary tuberculosis, diffuse panbronchiolitis, cystic fibrosis, clinically significant bronchiectasis, exacerbation of COPD or pneumonia in two months;
• prescribed immunosuppressive medications.

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

Location

Related Publications (1)

• Diao W, Labaki WW, Han MK, Yeomans L, Sun Y, Smiley Z, Kim JH, McHugh C, Xiang P, Shen N, Sun X, Guo C, Lu M, Standiford TJ, He B, Stringer KA. Disruption of histidine and energy homeostasis in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:2015-2025. doi: 10.2147/COPD.S210598. eCollection 2019.

  PMID: 31564849 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Chief in Department of Respiratory Medicine

Study Record Dates

• First Submitted: October 10, 2017
• First Posted: October 16, 2017
• Study Start: December 10, 2015
• Primary Completion: July 20, 2017
• Study Completion: July 20, 2017
• Last Updated: October 17, 2017

Record last verified: 2017-10

Locations

CN (1)