NCT03305744|Unknown
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Sponsor study identifier
observational
34
1 country
1
Study Start
January 30, 2018
Actual (reported)Primary Completion
August 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
August 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
This study evaluates cardiac structure and function differences between healthy endurance trained athletes with atrial fibrillation and healthy age matched endurance trained athletes without atrial fibrillation. It is hypothesized that despite having similar structural adaptations of the heart (due to endurance training), athletes with atrial fibrillation display will impaired heart functional measures compared to endurance athletes without atrial fibrillation.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 29, 2017
Actual (reported)October 10, 2017
Actual (reported)January 30, 2018
Actual (reported)August 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
August 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Left intra-atrial electromechanical delay (ms)
Left intra-atrial electromechanical delay will be measured using cardiac echocardiography at rest and during submaximal cycling. Left intra-atrial electromechanical delay will be measured as the time interval between the initiation of the P wave (on an electrocardiogram) to the beginning of the late diastolic wave (Am wave) on echocardiography.
baseline (day 1: at first visit, one time measure)
Left atrial reservoir function
baseline (day 1: at first visit, one time measure)
Left atrial volume (mL)
baseline (day 1: at first visit, one time measure)
Lifetime hours of Physical Activity (# of hours)
baseline (day 1: at first visit, one time measure)
Maximal oxygen consumption (VO2 max)
baseline (day 1: at first visit, one time measure)
These are middle-aged athletes who are diagnosed with paroxysmal Atrial Fibrillation in the last 4 years, but are otherwise free of disease.
These are middle-aged athletes who will serve as our control group- they have not been diagnosed with AF or any other disease.
Community sample from, but not limited to, various running, cycling, and rowing clubs for middle-aged athletes. Healthy endurance athletes will be selected from an existing study for convenience (non-probability sample). Endurance athletes with AF will be selected from the community (probability sample).
Goldring Center for High Performance
Toronto, Ontario, M5S 2C9, Canada
Molina L, Mont L, Marrugat J, Berruezo A, Brugada J, Bruguera J, Rebato C, Elosua R. Long-term endurance sport practice increases the incidence of lone atrial fibrillation in men: a follow-up study. Europace. 2008 May;10(5):618-23. doi: 10.1093/europace/eun071. Epub 2008 Apr 4.
Grimsmo J, Grundvold I, Maehlum S, Arnesen H. High prevalence of atrial fibrillation in long-term endurance cross-country skiers: echocardiographic findings and possible predictors--a 28-30 years follow-up study. Eur J Cardiovasc Prev Rehabil. 2010 Feb;17(1):100-5. doi: 10.1097/HJR.0b013e32833226be.
Emily Vecchiarelli, BKin
University of Toronto
Jack Goodman, PhD
University of Toronto
Paul Dorian, MD
Unity Health Toronto
First Submitted
September 29, 2017
First Posted
October 10, 2017
Study Start
January 30, 2018
Actual (reported)Primary Completion
August 2021
Estimated (date passed)Contact the study team to confirm eligibility.
Calvo N, Brugada J, Sitges M, Mont L. Atrial fibrillation and atrial flutter in athletes. Br J Sports Med. 2012 Nov;46 Suppl 1:i37-43. doi: 10.1136/bjsports-2012-091171.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
August 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
November 3, 2020
Record last verified: 2020-11
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