NCT03305354

Brief Summary

Veterans of the most recent wars in Afghanistan and Iraq (collectively, post 9/11 Veterans) have notable sleep problems including chronic insomnia. Here, the investigators plan to compare two groups of veterans with insomnia: (1) one group that completes a 6 week self-management-guided use of a mobile app based on cognitive behavioral therapy for insomnia (CBTI alone) and (2) one group that completes a 6 week combined self-management-guided use of the mobile CBTI app in addition to a physical activity (PA) intervention (CBTI + PA). The investigators hypothesize that the group receiving the adjunctive 6-week PA intervention will have better subjective and objective sleep, higher step counts, and better functional health and social and community integration than those receiving CBTI alone. This pilot work will provide evidence to guide the design of a future randomized controlled trial.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
33

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 4, 2017

Completed
5 days until next milestone

First Posted

Study publicly available on registry

October 9, 2017

Completed
4 months until next milestone

Study Start

First participant enrolled

January 31, 2018

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 27, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 27, 2019

Completed
Last Updated

August 20, 2019

Status Verified

August 1, 2019

Enrollment Period

1.4 years

First QC Date

October 4, 2017

Last Update Submit

August 19, 2019

Conditions

Keywords

mobile healthphysical activity

Outcome Measures

Primary Outcomes (2)

  • Insomnia Severity Index Total Score

    Total score on the Insomnia Severity Index

    6 weeks (Immediate post-intervention)

  • Pittsburgh Sleep Quality Index Total Score

    Total score on the Pittsburgh Sleep Quality Index Total Score

    6 weeks (Immediate post-intervention)

Secondary Outcomes (2)

  • Objective Sleep Efficiency

    6 weeks (Immediate post-intervention)

  • Daily step counts

    6 weeks (Immediate post-intervention)

Other Outcomes (5)

  • Functional Outcomes of Sleep

    6 weeks (Immediate post-intervention)

  • Social Engagement

    6 weeks (Immediate post-intervention)

  • Community Engagement

    6 weeks (Immediate post-intervention)

  • +2 more other outcomes

Study Arms (2)

CBTI app intervention

EXPERIMENTAL

Cognitive Behavioral Therapy for Insomnia delivered for 6 weeks via the CBT-I Coach app with use guided by a self-management guide

Behavioral: CBTI app intervention

CBTI app+Physical Activity Intervention

ACTIVE COMPARATOR

Cognitive Behavioral Therapy for Insomnia delivered for 6 weeks via the CBT-I Coach app with use guided by a self-management guide plus self-management guidance on increased step counts

Behavioral: CBTI app interventionBehavioral: Physical Activity intervention

Interventions

Self-management guided use of a mobile app called the CBT-I Coach to teach sleep hygiene and enhance sleep

CBTI app interventionCBTI app+Physical Activity Intervention

Self-management guided motivation to increase physical activity by increasing daily step counts

CBTI app+Physical Activity Intervention

Eligibility Criteria

Age21 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Eligible individuals will be US military Veterans
  • Eligible veterans will have served in the military during the post-9/11 period
  • Eligible veterans will have chronic, functionally impairing insomnia (i.e., at baseline veterans must have an Insomnia Severity Index score \> 10 with insomnia duration of at least 1 month, and impaired daytime functioning.
  • Eligible individuals must be willing to use devices (e.g., Fitbit, WatchPAT)provided by the study team.
  • Eligible individuals may have mild or moderate obstructive sleep apnea (as determined by one out of either of two nights with a WatchPAT-based Apnea-Hypopnea Index \[AHI\] \<= 30 events/hour of sleep).

You may not qualify if:

  • Periodic leg movements
  • Circadian rhythm disorder
  • Use of medications or health issues (e.g., permanent pacemaker, sustained non-sinus cardiac arrhythmias, finger deformity, etc.) that would interfere with the use of the WatchPAT sleep monitor
  • Severe obstructive sleep apnea (as determined by one out of either of two nights with a WatchPAT-based Apnea-Hypopnea Index \[AHI\] \> 30 events/hour of sleep)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Edith Nourse Rogers Memorial VA Hospital

Bedford, Massachusetts, 01730, United States

Location

Related Publications (2)

  • Kaitz J, Robinson SA, Petrakis BA, Reilly ED, Chamberlin ES, Wiener RS, Quigley KS. Veteran Acceptance of Sleep Health Information Technology: a Mixed-Method Study. J Technol Behav Sci. 2023;8(1):57-68. doi: 10.1007/s41347-022-00287-x. Epub 2022 Dec 13.

  • Reilly ED, Robinson SA, Petrakis BA, Gardner MM, Wiener RS, Castaneda-Sceppa C, Quigley KS. Mobile Intervention to Improve Sleep and Functional Health of Veterans With Insomnia: Randomized Controlled Trial. JMIR Form Res. 2021 Dec 9;5(12):e29573. doi: 10.2196/29573.

MeSH Terms

Conditions

Sleep Initiation and Maintenance DisordersMotor Activity

Condition Hierarchy (Ancestors)

Sleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesMental DisordersBehavior

Study Officials

  • Karen S Quigley, PhD

    Northeastern University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research Associate Professor

Study Record Dates

First Submitted

October 4, 2017

First Posted

October 9, 2017

Study Start

January 31, 2018

Primary Completion

June 27, 2019

Study Completion

June 27, 2019

Last Updated

August 20, 2019

Record last verified: 2019-08

Data Sharing

IPD Sharing
Will not share

Locations