Isolation and Establishment of Gustatory Cell Lines in Patients Operated on for Cancer of the Mobile Tongue - ImmortTasteCELL

NCT03305302 | Completed

• 1 other identifier: ZWETYENGA 2017
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

In terms of incidence, cancer of the tongue is one of the leading cancers in France. Moreover, this cancer is associated with physiological complications ranging from swallowing disorders to loss of taste. Following surgery, impaired perception of food taste may lead to cachexia. It is therefore necessary to carry out research in the field of impaired taste, notably with regard to the regeneration of taste buds. However, there is currently no available functional model of taste bud cells. It is therefore necessary to obtain a cell line of human taste cells. These immortalised human cells will allow us to better orient our investigations for applications in humans: search for and characterisation of "taste modifiers" synthesised using organic chemistry, able to trigger the perception of food in cases of taste loss or taste impairment. Moreover, given recent studies conducted by the investigating team proposing the existence of a fatty taste and its implication in obesity, the work of the team could be oriented towards the synthesis of lipid-receptor agonists, by analogy with artificial sweeteners instead of sugar. The availability of these chemical molecules would lead to a reduction in lipid intake as these agents contain no (or very few) calories. They will act as an organoleptic decoy.

Conditions

Cancer of the Tongue

Outcome Measures

Primary Outcomes (1)

• Immortalised human taste bud cells, isolated from the fungiform tastebuds of patients with cancer of the mobile tongue.

  through study completion, an average of 1 year

Interventions

Sample of cancerous epithelium from the tongue PROCEDURE

Harvesting and culture of cancerous epithelium from the surgical piece

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients undergoing surgery

You may qualify if:

• between 18 and 70 years old,
• with cancer of the mobile tongue
• requiring surgery

You may not qualify if:

• \- chronic smokers

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, 21000, France

Location

MeSH Terms

Conditions

Tongue Neoplasms

Condition Hierarchy (Ancestors)

Mouth Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Neoplasms; Mouth Diseases; Stomatognathic Diseases; Tongue Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 4, 2017
• First Posted: October 9, 2017
• Study Start: November 2, 2017
• Primary Completion: April 1, 2018
• Study Completion: April 1, 2018
• Last Updated: September 16, 2020

Record last verified: 2020-09

Locations

FR (1)