Factors Predicting Success in Lung Transplant Recipients Who Have Undergone Intensive Post-operative Rehabilitation

NCT03299504 | Completed

• 1 other identifier: RCS1
• Study Type: observational
• Target: 105
• Locations: 1 country
• Sites: 1

Brief Summary

This is a retrospective review of the COLTT program outcomes and factors that predict recovery of functional status after lung transplantation.

Conditions

Lung Transplant

Outcome Measures

Primary Outcomes (1)

• Time to reach program goals (days)

  The number of days in the COLTT program required to reach program goals ( see secondary outcomes measures)

  Through study completion, an average of 4 weeks

Secondary Outcomes (4)

• Gait speed (mph, % expected)

  Through study completion, an average of 4 weeks

• Single leg stance performance (seconds, % expected)

  Through study completion, an average of 4 weeks

• One-minute sit to stand performance (number, % expected)

  Through study completion, an average of 4 weeks

• Six minute walk distance (feet, % expected)

  Through study completion, an average of 4 weeks

Other Outcomes (1)

• Hospital readmission

  6 months

Interventions

Exercise OTHER

5 days per week, 2.5 hours per day strength, balance and endurance training on an outpatient basis

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Lung transplant recipients at IU Health Methodist Hospital. As part of standard care, all patients who survive to hospital discharge are referred by transplant pulmonologists to the COLTT program.

You may qualify if:

• All patients who completed the COLTT program from May, 2016 to July, 2017.

You may not qualify if:

• Any COLTT patients who were not new lung transplant recipients.

Sponsors & Collaborators

• Indiana University Health Methodist Hospital: lead

Study Sites (1)

IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States

Location

Related Publications (7)

• Wickerson L, Rozenberg D, Janaudis-Ferreira T, Deliva R, Lo V, Beauchamp G, Helm D, Gottesman C, Mendes P, Vieira L, Herridge M, Singer LG, Mathur S. Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach. World J Transplant. 2016 Sep 24;6(3):517-31. doi: 10.5500/wjt.v6.i3.517.

  PMID: 27683630 BACKGROUND

• Langer D, Burtin C, Schepers L, Ivanova A, Verleden G, Decramer M, Troosters T, Gosselink R. Exercise training after lung transplantation improves participation in daily activity: a randomized controlled trial. Am J Transplant. 2012 Jun;12(6):1584-92. doi: 10.1111/j.1600-6143.2012.04000.x. Epub 2012 Mar 5.

  PMID: 22390625 BACKGROUND

• Walsh JR, Chambers DC, Davis RJ, Morris NR, Seale HE, Yerkovich ST, Hopkins PM. Impaired exercise capacity after lung transplantation is related to delayed recovery of muscle strength. Clin Transplant. 2013 Jul-Aug;27(4):E504-11. doi: 10.1111/ctr.12163. Epub 2013 Jul 2.

  PMID: 23815281 BACKGROUND

• Strassmann A, Steurer-Stey C, Lana KD, Zoller M, Turk AJ, Suter P, Puhan MA. Population-based reference values for the 1-min sit-to-stand test. Int J Public Health. 2013 Dec;58(6):949-53. doi: 10.1007/s00038-013-0504-z. Epub 2013 Aug 24.

  PMID: 23974352 BACKGROUND

• Springer BA, Marin R, Cyhan T, Roberts H, Gill NW. Normative values for the unipedal stance test with eyes open and closed. J Geriatr Phys Ther. 2007;30(1):8-15. doi: 10.1519/00139143-200704000-00003.

  PMID: 19839175 BACKGROUND

• Middleton A, Fritz SL, Lusardi M. Walking speed: the functional vital sign. J Aging Phys Act. 2015 Apr;23(2):314-22. doi: 10.1123/japa.2013-0236. Epub 2014 May 2.

  PMID: 24812254 BACKGROUND

• Dierich M, Tecklenburg A, Fuehner T, Tegtbur U, Welte T, Haverich A, Warnecke G, Gottlieb J. The influence of clinical course after lung transplantation on rehabilitation success. Transpl Int. 2013 Mar;26(3):322-30. doi: 10.1111/tri.12048. Epub 2013 Jan 7.

  PMID: 23294442 BACKGROUND

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dedicated Physical Therapist

Study Record Dates

• First Submitted: September 8, 2017
• First Posted: October 3, 2017
• Study Start: September 26, 2017
• Primary Completion: April 1, 2018
• Study Completion: April 1, 2018
• Last Updated: August 24, 2018

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)