Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction

NCT03290599 | Completed

• 1 other identifier: 1
• Study Type: observational
• Target: 64
• Locations: 0 countries
• Sites: N/A

Brief Summary

Post-operative cognitive dysfunction is defined as a decrease in cognitive functions which develop following surgery and anesthesia administration that can last up to weeks or even months after surgery. In this study, our main objective was to investigate the effect of preoperative hospitalisation period on early post operative cognitive dysfunction development and its risk factors in patients who underwent total hip replacement surgery for hip fractures under regional anesthesia.

Conditions

Post Operative Cognitive Dysfunction

Keywords

Cognitive dysfunction; Hip Surgery; Mini mental Test,; Preoperative Hospitalisation; Spinal Anesthesia

Outcome Measures

Primary Outcomes (1)

• Post operative Cognitive Dysfunction

  Mini mental test

  change of Mini mental test score from hospitalisation time to post operative 24th hour

Study Arms (2)

No Post operative cognitive dysfunction

Patients who did not have any change or a change less than 4 points between MMT1 and MMT3

Other: Mini Mental and Modified Mini Mental Test

Post operative cognitive dysfunction

Patients with a difference more than 4 points between MMT1 and MMT3

Other: Mini Mental and Modified Mini Mental Test

Interventions

Mini Mental and Modified Mini Mental Test OTHER

Mini Mental Test was used for literate patients and Modified mini mental test was used for illiterated patients

No Post operative cognitive dysfunction; Post operative cognitive dysfunction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent total hip replacement surgery over 18 aged

You may qualify if:

• Patients who were planned to undergo total hip replacement surgery without cement over 18 years of age and within ASA Group 1, 2 and 3 according to ASA physical status score were included in the study.

You may not qualify if:

• Patients younger than 18, who did not speak Turkish, with known cancer history, previous steroid treatment, SVO history in last 6 months, with central nervous system diseases (current meningitis, encephalitis, tumors, major degenerative diseases), with dementia, Alzheimer's and Parkinson's Disease, pregnant patients, patients with neuropsychiatric diseases or received antidepressant, antipsychotic or anticonvulsive treatment in the last 6 months, uncooperative patients, patients with substance abuse problems, patients with severe organ failure (end-stage liver failure, dialysis-dependent kidney failure), patients who required ICU following surgery, patients where regional anesthesia was contraindicated (Idiopathic intracranial hypertension (IIH), clotting disorders, infection on operational site) were excluded from the study.

Sponsors & Collaborators

• Burcu Ozalp Horsanali: lead

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Burcu OZALP HORSANALI

Study Record Dates

• First Submitted: September 17, 2017
• First Posted: September 25, 2017
• Study Start: November 1, 2013
• Primary Completion: September 30, 2014
• Study Completion: September 30, 2014
• Last Updated: September 25, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will not share