Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line

NCT03288298 | Unknown Early Phase 1

• 1 other identifier: CEBD-CU-2017-09-23
• Study Type: interventional
• Target: 4
• Locations: 0 countries
• Sites: N/A

Brief Summary

In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line.

Conditions

Tongue Neoplasms; Carcinoma

Keywords

TSCC; OSCC; luteolin; nanoluteolin; nanotechnology; oral cancer; apoptosis; PCR; MTT; ELISA reader

Outcome Measures

Primary Outcomes (1)

• gene expression of Caspase 3 to detect apoptosis

  fold-changes

  6 hours

Secondary Outcomes (1)

• cell viability

  6 hours

Study Arms (2)

luteolin

EXPERIMENTAL

a natural extract derived flavinoids

Drug: luteolin

nano-luteolin

ACTIVE COMPARATOR

nano-particles derived from a natural extract luteolin

Drug: nano-luteolin

Interventions

luteolin DRUG

flavonoid natural extract

Also known as: 3',4',5,7-tetrahydroxyflavone

luteolin

nano-luteolin DRUG

nanoparticles of luteolin

Also known as: nanoluteolin

nano-luteolin

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC).
• Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term).
• Application of luteolin as a chemotherapeutic drug.

You may not qualify if:

• Any cancer cell line other than OSCC, TSCC and HNSCC cell lines.
• Luteolin glycosides.

Sponsors & Collaborators

• Cairo University: lead

Related Publications (1)

• Ding S, Hu A, Hu Y, Ma J, Weng P, Dai J. Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest. Tumour Biol. 2014 Apr;35(4):3053-60. doi: 10.1007/s13277-013-1396-5. Epub 2013 Nov 28.

  PMID: 24287949 BACKGROUND

MeSH Terms

Conditions

Tongue Neoplasms; Carcinoma; Mouth Neoplasms

Interventions

Luteolin

Condition Hierarchy (Ancestors)

Head and Neck Neoplasms; Neoplasms by Site; Neoplasms; Mouth Diseases; Stomatognathic Diseases; Tongue Diseases; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Intervention Hierarchy (Ancestors)

Flavones; Flavonoids; Chromones; Benzopyrans; Pyrans; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Officials

• Ahmed Elkhadem, PhD

  Center for Evidence Based Dentistry

  STUDY CHAIR

Central Study Contacts

Safaa M. Baz, Masters

CONTACT

002 01119777824; drsafaaelbaz@gmail.com

Safa F. Abd El-Ghani, PhD

CONTACT

002 01005198010; drsafa.fathy@yahoo.com

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer, Oral and Maxillofacial Pathology, BUE

Study Record Dates

• First Submitted: September 12, 2017
• First Posted: September 20, 2017
• Study Start: November 1, 2017
• Primary Completion: September 1, 2018
• Study Completion: April 1, 2019
• Last Updated: September 20, 2017

Record last verified: 2017-09