Brain Markers of Suicide Risk and Psychological Pain in Elderly Depressed Patients

NCT03287986 | Completed

• 1 other identifier: LOCAL/2016/FJMW-01
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this study is to show MRI functional and structural differences between depressed elderly patients with a history of attempted suicide compared to depressed elderly patients with no history of attempted suicide and to elderly subjects with no personal history of depression or attempted suicide (healthy controls).

Conditions

Depressive Disorder; Suicide, Attempted

Keywords

Elderly; MRI

Outcome Measures

Primary Outcomes (1)

• Brain functional activity during unfairness

  Contrast in BOLD signal measured by 3T-Magnetic Resonance Imaging (MRI) during the fair vs unfair trials of the Ultimatum Game

  Day 0

Secondary Outcomes (4)

• Brain structural volumes

  Day 0

• Brain structural connectivity

  Day 0

• Brain functional connectivity

  Day 0

• Correlation of MRI measures with psychological pain measures

  Day 0

Study Arms (3)

Suicide attempters

Depressed patients over 60 years of age with a personal history of suicide attempts scanned with MRI

Other: MRI

Patient controls

depressed patients over 60 years of age without a personal history of suicide attempt scanned with MRI

Other: MRI

Healthy Controls

Healthy subjects over 60 years, not depressed and without personal history of severe mental illness or suicide attempts, scanned with MRI

Other: MRI

Interventions

MRI OTHER

Structural and functional sequences

Healthy Controls; Patient controls; Suicide attempters

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly depressed patients

You may qualify if:

• The patient must have given their free and informed consent and signed the consent form
• be a member or beneficiary of a health insurance plan
• aged 60 years-old or more
• must be right-handed
• with a diagnosis of a current major depressive episode of moderate to severe severity according to diagnostic criteria.
• with or without a personal history of attempted suicide during life
• hospitalized or followed by a consultant in the department of Psychiatry of Nîmes University Hospital or in the Sophoras private clinic

You may not qualify if:

• under safeguard of justice
• refuses to sign the consent
• It is impossible to give the subject informed information
• Current psychotic symptoms.
• Bipolar disorder.
• The subject presents an acute somatic decompensation incompatible with the realization of this study.
• The patient presents a mental confusion or a known Mini Mental State Examination score \<24.
• Central neurological disease known in particular degenerative pathology, severe cranial trauma and severe cerebrovascular disease.
• Schizophrenia and other known psychotic disorders.
• Electroconvulsive therapy in the 12 months prior to study
• Inability to perform neuropsychological tests because of a language problem, poor understanding, a major tremor, inability to sit still, a major sight problem that cannot be corrected, or other severe cognitive impairment
• Contra-indication to magnetic resonance imaging (MRI): ferromagnetic implant in the body, piercing, claustrophobia, inability to remain elongated for 45 minutes.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes: lead

Study Sites (1)

CHU Nimes

Nîmes, 30029, France

Location

Biospecimen

Retention: NONE RETAINED

DNA, blood.

MeSH Terms

Conditions

Depressive Disorder; Suicide, Attempted

Condition Hierarchy (Ancestors)

Mood Disorders; Mental Disorders; Suicide; Self-Injurious Behavior; Behavioral Symptoms; Behavior

Study Officials

• Fabrice Jollant, MD PhD

  CHU Nîmes

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2017
• First Posted: September 19, 2017
• Study Start: August 18, 2017
• Primary Completion: December 13, 2019
• Study Completion: December 13, 2019
• Last Updated: March 9, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)