Management Of Acute Disseminating Encephalomyelitis

NCT03284801 | Unknown

• 1 other identifier: ADEM
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acute disseminated encephalomyelitis is an immune-mediated inflammatory demyelinating disease of the central nervous system, which is typically transitory and self-limiting. It is characterized by an acute or subacute encephalopathy with neurological deficits, and magnetic resonance imaging evidence of widespread demyelination that predominantly involves the white matter of the brain and spinal cord. In the absence of specific biological markers, the diagnosis of Acute disseminated encephalomyelitis is still based upon a combination of clinical and neuro imaging features and exclusion of diseases that mimic Acute disseminated encephalomyelitis

Conditions

Acute Disseminated Encephalomyelitis

Outcome Measures

Primary Outcomes (1)

• clinical audit on management of acute disseminating encephalomyelitis

  To improve diagnosis and management of acute disseminated encephalomyelitis in Neurology Unit of Assiut University Children Hospital and to decrease the mortality and residual deficits from this disease. The aim of this audit is to measure the current practice within the Neurology Unit of Assiut University Children Hospital team in the diagnosis and management of acute disseminated encephalomyelitis against the recommendations in American Academy of Neurology guidance by using checklist and designed questionnaire.

  within one year

Interventions

management of acute disseminating encephalomyelitis OTHER

clinical audit on management of acute disseminating encephalomyelitis

Eligibility Criteria

• Age: 12 Months - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

\- All patient presented with manifestation of acute disseminating encephalomyelitis admitted in Assiut University Children Hospital

You may qualify if:

• All patient presented with manifestation of acute disseminating encephalomyelitis admitted in Assiut University Children Hospital

You may not qualify if:

• Patients presented with viral encephalitis,bacterial meningitis
• Cases not fulfilling MRI criteria for diagnosis of acute disseminated encephalomyelitis

Sponsors & Collaborators

• Assiut University: lead

Related Publications (9)

• Wingerchuk DM. Postinfectious encephalomyelitis. Curr Neurol Neurosci Rep. 2003 May;3(3):256-64. doi: 10.1007/s11910-003-0086-x.

  PMID: 12691631 BACKGROUND

• Tenembaum S, Chitnis T, Ness J, Hahn JS; International Pediatric MS Study Group. Acute disseminated encephalomyelitis. Neurology. 2007 Apr 17;68(16 Suppl 2):S23-36. doi: 10.1212/01.wnl.0000259404.51352.7f.

  PMID: 17438235 BACKGROUND

• Menge T, Kieseier BC, Nessler S, Hemmer B, Hartung HP, Stuve O. Acute disseminated encephalomyelitis: an acute hit against the brain. Curr Opin Neurol. 2007 Jun;20(3):247-54. doi: 10.1097/WCO.0b013e3280f31b45.

  PMID: 17495616 BACKGROUND

• Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. 2000 Dec;123 Pt 12:2407-22. doi: 10.1093/brain/123.12.2407.

  PMID: 11099444 BACKGROUND

• Hynson JL, Kornberg AJ, Coleman LT, Shield L, Harvey AS, Kean MJ. Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology. 2001 May 22;56(10):1308-12. doi: 10.1212/wnl.56.10.1308.

  PMID: 11376179 BACKGROUND

• Anlar B, Basaran C, Kose G, Guven A, Haspolat S, Yakut A, Serdaroglu A, Senbil N, Tan H, Karaagaoglu E, Karli Oguz K. Acute disseminated encephalomyelitis in children: outcome and prognosis. Neuropediatrics. 2003 Aug;34(4):194-9. doi: 10.1055/s-2003-42208.

  PMID: 12973660 BACKGROUND

• Pohl D, Tenembaum S. Treatment of acute disseminated encephalomyelitis. Curr Treat Options Neurol. 2012 Jun;14(3):264-75. doi: 10.1007/s11940-012-0170-0.

  PMID: 22476745 BACKGROUND

• Cortese I, Chaudhry V, So YT, Cantor F, Cornblath DR, Rae-Grant A. Evidence-based guideline update: Plasmapheresis in neurologic disorders [RETIRED]: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2011 Jan 18;76(3):294-300. doi: 10.1212/WNL.0b013e318207b1f6.

  PMID: 21242498 BACKGROUND

• Keegan M, Pineda AA, McClelland RL, Darby CH, Rodriguez M, Weinshenker BG. Plasma exchange for severe attacks of CNS demyelination: predictors of response. Neurology. 2002 Jan 8;58(1):143-6. doi: 10.1212/wnl.58.1.143.

  PMID: 11781423 BACKGROUND

MeSH Terms

Conditions

Encephalomyelitis, Acute Disseminated

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Leukoencephalopathies; Brain Diseases; Central Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Marwa Alsaid Ahmed, resident doctor

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Farouk Alsayed hassanen, prof

CONTACT

01006178123; Farouk.hassan@med.eu.edu.eg

Eman Fath Allah, Lecturer

CONTACT

01115191158; Fathalaeman@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: September 8, 2017
• First Posted: September 15, 2017
• Study Start: January 1, 2018
• Primary Completion: January 1, 2019
• Study Completion: March 1, 2019
• Last Updated: September 15, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will not share