The Effect of Menstrual Cycle On IL-6, TNF-α And Periodontal Status

NCT03281109 | Unknown

• 1 other identifier: YuzuncuYıl4
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Aim: Women's menstrual cycle is controlled by the secretion of sex hormones. Sex steroid hormones are thought to be affect to periodontal tissues, wound healing, periodontal disease progression and bone turn over. The aim the study is to evaluate clinical periodontal parameters and interleukin- 6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) in menstrual cycle. Material and methods: Twenty-five patients were included in this study clinical periodontal parameters and levels of IL-6 and TNF α in gingival crevicular fluid were evaluated at three periods of menstrual cycle (menstruation day (MD)-ovulation day(OD)-premenstruation day (PmD)). Levels of IL-6 and TNF α in gingival crevicular fluid were determined by ELISA.

Conditions

Menstrual Cycle-Associated Gingivitis

Keywords

menstrual cycle; gingivitis; interleukin 1; tumor necrosis factor alpha

Outcome Measures

Primary Outcomes (1)

• periodontal clinical parameters

  gingival index: according to Silness and Löe gingival index plaque index: according to Löe and Silness plaque index probing depth the distance between gingival margin to periodontal sulcus bottom (mm) IL-6 concentration (pg/microliter) TNF- alpha concentration (pg/microliter)

  1 menstrual cycle (approximately 1 month) every patient follow up

Interventions

diagnosis DIAGNOSTIC_TEST

diagnosis with ELISA

Eligibility Criteria

• Age: 20 Years - 29 Years
• Gender Eligibility Details: Only Female
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

25 women were included in this longitudinal, prospective study in Yuzuncu Yil University, Faculty of Dentistry, Department of Periodontology

You may qualify if:

• premenopausal women, age 20-35 to years;
• normal and steady menstrual cycle (25 to 31 days long);
• available for clinical examination;
• non-smoking;
• antibiotic therapy or use of nonsteroidal anti-inflammatory drugs within the past 6 months;
• healthy systemic status;
• normal body mass index;
• healthy periodontium.

You may not qualify if:

• pregnancy;
• use of oral contraceptives;
• metabolic or systemic condition that might affect the periodontium;
• antibiotic therapy or use of nonsteroidal anti-inflammatory drugs within the past 6 months;
• periodontitis;
• smoking and
• with the diagnosis of polycystic over or hyperandrogenism according to Rotterdam diagnostic criteria

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Study Sites (1)

Yuzuncu Yıl University

Van, 65080, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Gingivitis

Interventions

Diagnosis

Condition Hierarchy (Ancestors)

Infections; Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• hacer sahin aydinyurt

  yuzuncu yil universtiy

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: August 16, 2017
• First Posted: September 13, 2017
• Study Start: July 26, 2017
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2018
• Last Updated: February 6, 2018

Record last verified: 2018-02

Locations

TU (1)