Muscle Strength Training for Older Adults With Type II Diabetes

NCT03280758 | Unknown

• 1 other identifier: 02
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomised controlled trial aims to investigate a resistance training program for improving glycemic control, muscle mass, strength and functional performance in older patients with Type II Diabetes (T2 DM). 60 subjects will be randomly allocated to either a muscle strengthening group or a no exercise control group. Muscle strengthening group will receive resistance training 3 times per week (1 hour/session). The control group will not receive any training but can continue usual medical care and daily activities. Primary outcomes: glycemic control and lipid profile Secondary outcomes: muscle mass and strength, and functional capacity Data will be collected at baseline (pre-test) and after a 4-month intervention (post-test).

Conditions

Type 2 Diabetes Mellitus

Keywords

Resistance training; Diabetes Mellitus; blood-glucose control; Muscle; Function

Outcome Measures

Primary Outcomes (2)

• Fasting glucose level

  4 months

• Lipid profiles

  HDL, LDL, Trig

  4 months

Secondary Outcomes (3)

• Muscle strength

  4 months

• Muscle mass

  4 months

• Functional performance

  4 months

Study Arms (2)

Muscle strengthening group

EXPERIMENTAL

Participants will be required to perform muscle strengthening exercises 3 hours per week. Close kinetic chain exercises will be performed progressively according to the ACSM guidelines over the 4-month intervention period. The exercise intervention will be conducted by an experienced sports trainer.

Behavioral: Muscle Strengthening exercises

Control group

NO INTERVENTION

No exercise training.

Interventions

Muscle Strengthening exercises BEHAVIORAL

Participants will be required to participate in resistance training 3 hours per week.

Muscle strengthening group

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• T2 DM
• years old
• ability to perform exercise

You may not qualify if:

• Advanced hypertension (≥ 160/100 mm Hg)
• severe obesity (BMI ≥ 48kg/m2)
• insulin pump user
• coronary heart disease history
• chronic obstructive pulmonary disease
• advanced neuropathy
• learning or mental disorder, or
• any other diseases that prevent subjects from exercising safely.
• Those who participate in regular resistance or aerobic exercises will also be excluded.

Sponsors & Collaborators

• The University of Hong Kong: lead

Related Publications (8)

• Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet. 2011 Jul 9;378(9786):169-81. doi: 10.1016/S0140-6736(11)60614-4. Epub 2011 Jun 24.

  PMID: 21705072 BACKGROUND

• Leenders M, Verdijk LB, van der Hoeven L, Adam JJ, van Kranenburg J, Nilwik R, van Loon LJ. Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging. J Am Med Dir Assoc. 2013 Aug;14(8):585-92. doi: 10.1016/j.jamda.2013.02.006. Epub 2013 Mar 26.

  PMID: 23537893 BACKGROUND

• Shishikura K, Tanimoto K, Sakai S, Tanimoto Y, Terasaki J, Hanafusa T. Association between skeletal muscle mass and insulin secretion in patients with type 2 diabetes mellitus. Endocr J. 2014;61(3):281-7. doi: 10.1507/endocrj.ej13-0375. Epub 2014 Jan 10.

  PMID: 24420336 BACKGROUND

• Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, Zimmet P. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 2002 Oct;25(10):1729-36. doi: 10.2337/diacare.25.10.1729.

  PMID: 12351469 BACKGROUND

• American Diabetes Association. Diabetes mellitus and exercise. Diabetes Care. 2000 Jan;23 Suppl 1:S50-4. No abstract available.

  PMID: 12017678 BACKGROUND

• Albright A, Franz M, Hornsby G, Kriska A, Marrero D, Ullrich I, Verity LS. American College of Sports Medicine position stand. Exercise and type 2 diabetes. Med Sci Sports Exerc. 2000 Jul;32(7):1345-60. doi: 10.1097/00005768-200007000-00024.

  PMID: 10912903 BACKGROUND

• Black LE, Swan PD, Alvar BA. Effects of intensity and volume on insulin sensitivity during acute bouts of resistance training. J Strength Cond Res. 2010 Apr;24(4):1109-16. doi: 10.1519/JSC.0b013e3181cbab6d.

  PMID: 20093961 BACKGROUND

• Baldi JC, Snowling N. Resistance training improves glycaemic control in obese type 2 diabetic men. Int J Sports Med. 2003 Aug;24(6):419-23. doi: 10.1055/s-2003-41173.

  PMID: 12905089 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Siu Ming Fong, PhD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Siu Ming Fong, PhD

CONTACT

28315260; smfong@hku.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcome assessor will not know the intervention of each subjects
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: September 5, 2017
• First Posted: September 12, 2017
• Study Start: October 1, 2017
• Primary Completion: January 30, 2019
• Study Completion: August 30, 2019
• Last Updated: September 12, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will not share