Assessment of Pulmonary Artery Pressure and Right Sided Hemodynamics in Patients With OSA Before and After CPAP TTT

NCT03276611 | Unknown

• 1 other identifier: 17100139
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Obstructive sleep apnea (OSA) is a frequent sleep-related breathing disorder with an incidence of 5-20% in the middle-aged population in Europe and Northern America . plumonary hypertension is present in 12%-34% of patients with osa.continous positive air way pressureis the main standard treatment ofOSA.Echocardiograghy is the most common non invasive imaging method for assessment the effect on right ventricular function.

Conditions

Obstructive Sleep Apnea of Adult

Keywords

Assessment; pulmonary; artery; right; sided; hemodynamics; patients; sleep; apnea; syndrome; contionous; positive; air; way; pressure; treatment

Outcome Measures

Primary Outcomes (1)

• Impact of OSA and CPAP therapy on pulmonary artery pressure and right sided hemodynamics

  Transthoracic echocardiography to determine right ventricle and right atrium functional parameters and dimensions and pulmonary artery systolic pressure, echocardiography will be planned for evaluation of OSA before initiation of CPAP therapy and after 3 month of CPAP therapy.

  Transthoracic echocardiography will be planned for evaluation of OSA patients regularly used CPAP (at least 5hrs/night) before and after 3 month of initiation of CPAP therapy.

Interventions

echocardiograghy OTHER

transthoracic echocardiograghy

Eligibility Criteria

• Age: Up to 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients will be evaluated at the sleep lap of chest department of assiut university hospital over 1 year will be enrolled in the study.

You may qualify if:

• Moderate and severe OSA and candidates for initiation of CPAP therapy.

You may not qualify if:

• Significant lung disease ,lfet sided heart failure,end stage malignancy and advanced organ failure.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Amr Youssef

Asyut, 71111, Egypt

RECRUITING

Related Publications (4)

• Park JG, Ramar K, Olson EJ. Updates on definition, consequences, and management of obstructive sleep apnea. Mayo Clin Proc. 2011 Jun;86(6):549-54; quiz 554-5. doi: 10.4065/mcp.2010.0810.

  PMID: 21628617 BACKGROUND

• Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, Morehead A, Kitzman D, Oh J, Quinones M, Schiller NB, Stein JH, Weissman NJ; American Society of Echocardiography. American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr. 2004 Oct;17(10):1086-119. doi: 10.1016/j.echo.2004.07.013. No abstract available.

  PMID: 15452478 BACKGROUND

• Kim SH, Cho GY, Shin C, Lim HE, Kim YH, Song WH, Shim WJ, Ahn JC. Impact of obstructive sleep apnea on left ventricular diastolic function. Am J Cardiol. 2008 Jun 1;101(11):1663-8. doi: 10.1016/j.amjcard.2008.01.056. Epub 2008 Apr 18.

  PMID: 18489948 BACKGROUND

• Jurcut R, Giusca S, La Gerche A, Vasile S, Ginghina C, Voigt JU. The echocardiographic assessment of the right ventricle: what to do in 2010? Eur J Echocardiogr. 2010 Mar;11(2):81-96. doi: 10.1093/ejechocard/jep234. Epub 2010 Feb 2.

  PMID: 20124362 BACKGROUND

MeSH Terms

Conditions

Apnea; Syndrome

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Disease; Pathologic Processes

Study Officials

• Yahia Shabeeb, MBBCH

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amr Youssef, MD

CONTACT

01006554042; amryoussef111@yahoo.com

Hamdy ShamsEdeen, MD

CONTACT

01065601161; ashams98@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: August 21, 2017
• First Posted: September 8, 2017
• Study Start: April 1, 2017
• Primary Completion: March 31, 2018
• Study Completion: December 31, 2018
• Last Updated: September 8, 2017

Record last verified: 2017-08

Locations

EG (1)