Effect of Maternal BMI and Type of Infants Feeding on IGF-1 in Infant

NCT03275272 | Unknown

• 1 other identifier: IGF-1level in infants
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

IGF-I is a mitogenic and antiapoptotic. paracrine growth factor expressed in all fetal organ. and is essential in fetal and neonatal growth, differentiation and development Several lines of evidence suggest that IGF-I levels are associated with birth weight -furthermore higher IGF-I levels are associated with higher BW, but not with lower birth weight\]. In adulthood, elevated concentrations of IGF-I are associated with an increased risk of obesity and many cancers, including breast, lung, head and neck, colorectal, pancreas, synovial sarcoma, and prostate canc. Although concentrations of circulating IGF-I levels vary considerably by race/ethnicity and maternal pre-pregnancy obesity, few studies included African American women an ethnic group that has an almost 9% higher BMI than European-American women

Conditions

IGF1 Deficiency

Outcome Measures

Primary Outcomes (1)

• IGF-1 level in infants

  Effect of maternal BMI and type of feeding of infants on IGF-1on infants

  One year

Study Arms (1)

level of IGF-1 in infant

OTHER

Measurment of blood level of IGF-1 In infants

Diagnostic Test: level of IGF-1 in infants

Interventions

level of IGF-1 in infants DIAGNOSTIC_TEST

Measurment of blood level of IGF-1 in infants

level of IGF-1 in infant

Eligibility Criteria

• Age: 2 Months - 3 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• infants from two to three month and thier mother

You may not qualify if:

• VLBW. 2-preterm infants. 3-IUGR 4-mother with hormonal disturbance

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Hansen-Pupp I, Lofqvist C, Polberger S, Niklasson A, Fellman V, Hellstrom A, Ley D. Influence of insulin-like growth factor I and nutrition during phases of postnatal growth in very preterm infants. Pediatr Res. 2011 May;69(5 Pt 1):448-53. doi: 10.1203/PDR.0b013e3182115000.

  PMID: 21263374 BACKGROUND

• Lineham JD, Smith RM, Dahlenburg GW, King RA, Haslam RR, Stuart MC, Faull L. Circulating insulin-like growth factor I levels in newborn premature and full-term infants followed longitudinally. Early Hum Dev. 1986 Feb;13(1):37-46. doi: 10.1016/0378-3782(86)90096-4.

  PMID: 3956421 RESULT

• Hikino S, Ihara K, Yamamoto J, Takahata Y, Nakayama H, Kinukawa N, Narazaki Y, Hara T. Physical growth and retinopathy in preterm infants: involvement of IGF-I and GH. Pediatr Res. 2001 Dec;50(6):732-6. doi: 10.1203/00006450-200112000-00017.

  PMID: 11726732 RESULT

MeSH Terms

Conditions

Insulin-Like Growth Factor I Deficiency

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Measurment of blood level of IGF-1 and Maternal BMI
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Nesma Mohamed Ezz ElDien Shahata

Model Details: Measurment of maternal BMI and serum level if IGF-1 in infant

Study Record Dates

• First Submitted: September 6, 2017
• First Posted: September 7, 2017
• Study Start: December 1, 2017
• Primary Completion: December 1, 2018
• Study Completion: December 1, 2018
• Last Updated: September 7, 2017

Record last verified: 2017-09