NCT03272243

Brief Summary

A prospective study included 91 patients, who had single level thoracolumbar fracture with Cobb's angle ≤ 25⁰, underwent posterior fixation. Forty four patients underwent short segment fixation with screws into the index level, and 47 patients underwent long segment fixation with skipped index level. The angle of correction, pain, and neurological state were regularly assessed

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
91

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Feb 2012

Longer than P75 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2012

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2016

Completed
9 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2016

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

August 31, 2017

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 5, 2017

Completed
Last Updated

September 6, 2017

Status Verified

September 1, 2017

Enrollment Period

4.1 years

First QC Date

August 31, 2017

Last Update Submit

September 1, 2017

Conditions

Keywords

thoracolumbar fractureshort segment fixationlong segment fixationindex level

Outcome Measures

Primary Outcomes (3)

  • Change in pain

    Visual analogue scale assessment

    3rd, 6th, 9th, 12th months

  • Change in disability

    assessment of Oswestry Disability Scale

    3rd, 6th, 9th, 12th months

  • Change in angle of correction

    Measurement of Cobb's angle

    3rd, 6th, 9th, 12th months

Study Arms (2)

Short Segment posterior spine fixation

ACTIVE COMPARATOR

Short segment transpedicular screw fixation with inclusion of the index level

Procedure: short segment posterior spine fixation

Long Segment posterior spine fixation

ACTIVE COMPARATOR

Long segment transpedicular screw fixation with escape of the index level

Procedure: long segment posterior spine fixation

Interventions

Short Segment posterior spine fixation
Long Segment posterior spine fixation

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • wedge fracture or burst fracture with Thoraco-Lumbar Injury Classification and Severity (TLICS) score ≥ 4
  • Single level fracture
  • Less than 50% of spinal canal compromised
  • Mild kyphosis or scoliosis
  • Cobb's angle ≤ 25˚
  • with or without neurological deficit

You may not qualify if:

  • patients with multiple level fractures
  • patients with more than 50% spinal canal compromise
  • patients who needed anterior approach to decompress the canal
  • patients who have fracture dislocation and / or marked kyphosis and scoliosis with Cobb's angle \>25⁰
  • patients who needed 360⁰ fixation with long segment fixation to maintain the angle of correction.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Spinal Fractures

Condition Hierarchy (Ancestors)

Spinal InjuriesBack InjuriesWounds and InjuriesFractures, Bone

Study Officials

  • Walid A Abdel Ghany, M.D., Ph.D

    Associate Professor of Neurosurgery

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Fellow of functional neurosurgery division

Study Record Dates

First Submitted

August 31, 2017

First Posted

September 5, 2017

Study Start

February 1, 2012

Primary Completion

February 28, 2016

Study Completion

November 30, 2016

Last Updated

September 6, 2017

Record last verified: 2017-09

Data Sharing

IPD Sharing
Will share
Shared Documents
STUDY PROTOCOL, CSR