Abdominal Ultrasonography in Urinary Tract Infection - When and Why?

NCT03270540 | Completed

• 1 other identifier: WarsawMU2W9
• Study Type: observational
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

Urinary tract infection (UTI) in a child may be the first symptom of congenital anomaly of the kidneys and the urinary tract (CAKUT). Thus, imaging diagnostics are warranted in children with first episode of UTI. Abdominal ultrasonography (USG) is the first line imaging modality in evaluating children with UTI. Abnormalities suggesting CAKUT found on USG are an indication for further, more invasive tests. The timing of USG in UTI depends on the clinical situation. It always should be performed urgently when serious acute complications of UTI are suspected. However, appropriate timing of USG in children responding well to therapy, is a matter of debate. According to animal studies, E. coli produces toxin which dilates the urinary tract. This may result in misleading picture on USG in acute phase of infection. Guidelines on UTI management in children differ in respect to recommended USG timing. The purpose of the study is to investigate how UTI does affect USG results in children and when its effect subsides. Methods 150 children up to 3 years of age, with the first episode of UTI, will be included in our study. Three USG examinations will be performed by single radiologist in every child:

1. 1.in the first day of treatment,
2. 2.two weeks after treatment initiation,
3. 3.four weeks after treatment initiation. Age, gender, etiologic factor, C-reactive protein concentration and white blood cells count will be included in statistical analysis.

Conditions

Urinary Tract Infections; UTI

Outcome Measures

Primary Outcomes (1)

• USG abnormality persistence

  significant abnormalities within kidney size or calices/pelvis/ureter dimensions, reproducible in subsequent USG examinations

  4 weeks

Eligibility Criteria

• Age: Up to 3 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

children with UTI treated in Medical University of Warsaw Children's Hospital

You may qualify if:

• \- laboratory diagnosis of UTI in a child (positive leucocyturia and significant bacteriuria)

You may not qualify if:

• known previous UTIs
• known congenital abnormality of the kidney and the urinary tract (CAKUT)

Sponsors & Collaborators

• Medical University of Warsaw: lead

Study Sites (1)

Medical University of Warsaw Children's Hospital

Warsaw, 02091, Poland

Location

Related Links

• National Institute for Health and Care Excellence. Urinary tract infections in children and young people 2013 July
• European Association of Urology; European Society for Pediatric Urology Urinary tract infections in children: (EAU/ESPU) guidelines.
• Canadian Paediatric Society, Urinary tract infection in infants and children: Diagnosis and management

MeSH Terms

Conditions

Urinary Tract Infections

Condition Hierarchy (Ancestors)

Infections; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: August 29, 2017
• First Posted: September 1, 2017
• Study Start: March 13, 2017
• Primary Completion: November 18, 2018
• Study Completion: November 18, 2018
• Last Updated: November 26, 2018

Record last verified: 2018-11

Locations

PL (1)