Age Gene/Environment Susceptibility Reykjavik Study

NCT03269656 | Completed

• 3 other identifiers: IHANO1-AG-1-2100ZIAEY000401
• Study Type: observational
• Target: 5,764
• Locations: 0 countries
• Sites: N/A

Brief Summary

5764 men and women in Iceland, aged 66 to 96 years entered the Ages Gene/Environment Susceptibility (AGES) - Reykjavik Study. Serum 25(OH)D was measured in 5,519 of all 5,764 (96%) participants at study entry in year 2002 through 2006. The main emphasis was on exploring whether pre-diagnostic serum levels of 25(OH)D were associated with survival after cancer diagnosis.

Conditions

Neoplasms

Keywords

Vitamin D; Cancer; Survival

Outcome Measures

Primary Outcomes (2)

• Overall survival

  The association between pre-diagnostic 25(OH)D levels in cancer patients and overall survival

  From date of diagnosis until death or censored at end of the follow-up (December 31, 2014)

• Cancer survival

  The association between pre-diagnostic 25(OH)D levels in cancer patients and cancer survival

  From date of diagnosis until cancer death or censored at the end of the follow-up (December 31, 2014)

Secondary Outcomes (1)

• Cancer diagnosis

  From date of blood draw (study entry) until cancer diagnosis, death or end of the observation period (December 31, 2014) whichever occurred first

Study Arms (1)

AGES-Reykjavik participants

Exploring whether pre-diagnostic serum levels of 25(OH)D among older individuals living in Iceland were associated with survival after cancer diagnosis. We also assessed the risk of being diagnosed with cancer in association with 25(OH)D levels.

Eligibility Criteria

• Age: 66 Years - 98 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

In 1967, all 30,795 men and women living in the capital area of Iceland and born between 1907 and 1935 were invited by the Icelandic Heart Association to join a prospective cohort study. Approximately 19,000 attended the clinic at least once and became participants of the Reykjavik Study. Subsequently, in 2002, a random sample of the cohort comprising 5,764 men and women who were still alive in Iceland and aged 66 to 96 years entered the Ages Gene/Environment Susceptibility (AGES) - Reykjavik Study

You may qualify if:

• To participate in the AGES-Reykjavik study

You may not qualify if:

• To be diagnosed with cancer before study entry

Sponsors & Collaborators

• Icelandic Heart Association: lead
• University of Iceland: collaborator

Related Publications (1)

• Harris TB, Launer LJ, Eiriksdottir G, Kjartansson O, Jonsson PV, Sigurdsson G, Thorgeirsson G, Aspelund T, Garcia ME, Cotch MF, Hoffman HJ, Gudnason V. Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol. 2007 May 1;165(9):1076-87. doi: 10.1093/aje/kwk115. Epub 2007 Mar 10.

  PMID: 17351290 BACKGROUND

Related Links

• Age, Gene/Environment Susceptibility-Reykjavik Study: Multidisciplinary Applied Phenomics

Biospecimen

Retention: SAMPLES WITH DNA

Serum samples

MeSH Terms

Conditions

Neoplasms

Study Officials

• Johanna Torfadottir, PhD

  University of Iceland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 30, 2017
• First Posted: September 1, 2017
• Study Start: January 1, 2002
• Primary Completion: January 31, 2006
• Study Completion: December 31, 2014
• Last Updated: September 1, 2017

Record last verified: 2017-08