Neurophysiological Examination in Patients With Brain Death

NCT03262896 | Completed DMC

• 1 other identifier: EMG in Brain Death
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

This study examines muscle movements of elecromyography in adults with brain death. Half of the participants will have brain death, the other half will be healthy volunteers.

Conditions

Brain Death

Keywords

Brain Death; Spinal Reflex; Electromyography

Outcome Measures

Primary Outcomes (1)

• Axonal response

  Measure of axonal response by electromyography

  Within 72 hours from brain death diagnosis

Study Arms (1)

Patients with brain death

Ten patients with definite etiology, who were diagnosed with brain death because of Apnea test positive and / or cranial reflexes were not available and were male and female patients aged 18-72 years

Eligibility Criteria

• Age: 18 Years - 72 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients in the adult intensive care unit

You may qualify if:

• Adult patients with definite diagnosis of brain death,
• Patients with permission from their parents,
• Patients without trauma of medullaspinalis and peripheral nerve injuries,
• Patients without previously known muscle disease (Myasthenia gravis, myopathy, etc.),
• Patients with previously unknown neurological disease (Amyotrophic Lateral Sclerosis, Multiple sclerosis, Guillain Barre syndrome, Poliomyelitis, etc.),
• Patients who have not previous systemic diseases (Connective Tissue Disease, Diabetes mellitus, Chronic renal failure, etc.).

You may not qualify if:

• Uncertain brain death,
• Patients without permission of family members,
• Younger than 18 years old and older than 72 years,
• Patients with medulla spinalis and peripheral nerve injuries,
• Patients with known muscle disease (Myasthenia gravis, myopathy, etc.),
• Patients with neurological disease (Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Guillain Barre Syndrome, Poliomyelitis, etc.),
• Patients with previous systemic diseases (Connective Tissue Disease, Diabetes, Chronic Kidney Failure, etc.)

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Study Sites (1)

Yuzuncu Yil University, School of Medicine

Van, Tusba / Zeve Kampus, 65080, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Brain Death

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Coma; Unconsciousness; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Death; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Hilmi Demirkiran, MD

  Department of Anethesiology and Reanimation

  STUDY DIRECTOR

• Aydin Cagac, MD

  Department of Neurology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: August 19, 2017
• First Posted: August 25, 2017
• Study Start: May 15, 2017
• Primary Completion: May 15, 2018
• Study Completion: September 15, 2019
• Last Updated: October 10, 2019

Record last verified: 2019-10

Locations

TU (1)