The Effect of Obstructive Sleep Apnea and Its Treatment on Decision Making

NCT03262519 | Unknown

• 1 other identifier: 170683
• Study Type: observational
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

Obstructive sleep apnea (OSA) is an extremely common disease with inadequately explored neurocognitive consequences. The investigators will study OSA patients before and after treatment to understand how OSA changes decision making abilities, and whether treatment can reverse such cognitive changes. These results could provide deeper insight into how OSA affects decision making either temporarily or permanently, and provide another rationale or motivation for treatment of OSA in adults.

Conditions

Obstructive Sleep Apnea

Outcome Measures

Primary Outcomes (1)

• Change in Iowa Gambling Task

  The Iowa Gambling Task is a psychological task thought to simulate real-life decision making. It is completed on a computer and takes about 10 minutes. It is widely used in research on cognition.

  2 months (baseline, 2 months later)

Secondary Outcomes (4)

• Change in Cognitive Reflection Test (CRT)

  2 months (baseline, 2 months later)

• Change in Intertemporal Choice

  2 months (baseline, 2 months later)

• Change in Balloon Analogue Risk Task (BART)

  2 months (baseline, 2 months later)

• Change in Epworth Sleepiness Score

  2 months (baseline, 2 months later)

Study Arms (1)

Patients at UCSD Sleep Medicine Clinic

Patients referred for sleep testing (either home sleep testing or in-lab full polysomnography) will be approached for participation.

Diagnostic Test: Computer based neurocognitive testing

Interventions

Computer based neurocognitive testing DIAGNOSTIC_TEST

Iowa Gambling Task, The Balloon Task, Intertemporal choices task, Cognitive Reflection Test, Physiological and self-reported measures of OSA/sleep related symptoms, General health and physiological measures.

Patients at UCSD Sleep Medicine Clinic

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects aged 18-75 referred to the UCSD Sleep clinic for either home or in-laboratory testing will be considered for inclusion in the study.

You may qualify if:

• participants will be enrolled at the UCSD Sleep Clinic at Chancellor Park.
• Ages 18-75
• Gender: Men and woman
• Ethnic background: All
• Health Status: to the UCSD Sleep clinic for either home or in-laboratory testing

You may not qualify if:

• Ongoing CPAP treatment for OSA
• Inability to use a tablet device (e.g. no reading glasses, or unfamiliar with devices).
• Severe cardiopulmonary disorder that requires treatment with supplemental oxygen therapy.
• Inability to speak English fluently, as some of the questionnaires/tests are only validated in English.

Sponsors & Collaborators

• University of California, San Diego: lead

Study Sites (1)

University of California, San Diego

San Diego, California, 92093, United States

Location

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Clinical Professor

Study Record Dates

• First Submitted: July 25, 2017
• First Posted: August 25, 2017
• Study Start: July 20, 2017
• Primary Completion: May 1, 2019
• Study Completion: December 1, 2022
• Last Updated: March 7, 2022

Record last verified: 2022-03

Locations

US (1)