Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain
1 other identifier
interventional
125
1 country
1
Brief Summary
The aim of this study is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in knee osteoarthritis patients to elucidate the underlying brain mechanisms of mind-body interaction, imagery, and acupuncture.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2019
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 22, 2017
CompletedFirst Posted
Study publicly available on registry
August 25, 2017
CompletedStudy Start
First participant enrolled
August 4, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 29, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2023
CompletedResults Posted
Study results publicly available
November 5, 2025
CompletedNovember 5, 2025
October 1, 2025
4.1 years
August 22, 2017
December 8, 2023
October 21, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
fMRI Signal Increases
fMRI measures changes in brain activity by detecting fluctuations in blood oxygenation levels. The primary signal used in fMRI is the Blood Oxygen Level Dependent (BOLD) signal, which reflects neuronal activity indirectly through hemodynamic responses.
Collected once during the first treatment session
Secondary Outcomes (1)
PAG Resting State Connectivity
baseline and after one month treatment
Study Arms (4)
VGAIT
EXPERIMENTALVGAIT Control
SHAM COMPARATORReal Acupuncture
ACTIVE COMPARATORSham Acupuncture
PLACEBO COMPARATORInterventions
Patients will watch a video of themselves receiving acupuncture or a control video or receive real or sham acupuncture treatment.
Eligibility Criteria
You may qualify if:
- Right-handed
- Knee osteoarthritis patients
- Ages 40 to 70 years old
You may not qualify if:
- Any contraindications to MRI scanning (claustrophobia, metal implants)
- Current or past history of major medical, neurological, or psychiatric illness other than knee osteoarthritis (including high blood pressure, heart disorders, impaired elimination, stomach problems, major kidney or liver problems, bleeding problems, severe dehydration, history of diabetes, history of asthma or other respiratory condition)
- Pregnancy
- Non fluent English speaker
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Athinoula A. Martinos Center for Biomedical Imaging
Charlestown, Massachusetts, 02129, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Prof. Jian Kong
- Organization
- Massachusetts General Hospital
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
August 22, 2017
First Posted
August 25, 2017
Study Start
August 4, 2019
Primary Completion
August 29, 2023
Study Completion
August 31, 2023
Last Updated
November 5, 2025
Results First Posted
November 5, 2025
Record last verified: 2025-10
Data Sharing
- IPD Sharing
- Will not share