No Association Between Vitamin C and E Supplementation, Frailty, and Grip Strength Over Five Years: The CoLaus Study
CoLaus
1 other identifier
observational
2,711
1 country
1
Brief Summary
To assess the cross-sectional and 5-year prospective association between self-reported vitamin C+E dietary supplementation and markers of grip strength and frailty in community-dwelling Swiss adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 10, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
August 10, 2017
CompletedFirst Submitted
Initial submission to the registry
August 14, 2017
CompletedFirst Posted
Study publicly available on registry
August 23, 2017
CompletedAugust 23, 2017
August 1, 2017
1 month
August 14, 2017
August 21, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Grip strength
Grip strength was assessed using the Baseline® Hydraulic Hand Dynamometer (Fabrication Enterprises Inc, Elmsford, NY, USA) with the subject seated, shoulders adducted and neutrally rotated, elbow flexed at 90°, forearm in neutral position, and wrist between 0 and 30° of dorsiflexion per American Society of Hand Therapists's guidelines (26). Three measurements were performed successively with the subject's right hand, and the highest value (expressed in kg), along with the participant's dominant hand choice, was recorded.
Between April 2009 and September 2012, and 5.5 years afterwards
Secondary Outcomes (1)
Low grip strength
Between April 2009 and September 2012, and 5.5 years afterwards
Interventions
taking vitamin supplements
Eligibility Criteria
All inhabitants of Lausanne city, Switzerland, aged 35 to 75 at the time of the Baseline study (2003-2006)
You may not qualify if:
- missing grip strength;
- missing covariates
- did not complete the second follow-up
- missing grip strength at the second follow-up.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre Hospitalier Universitaire Vaudois
Lausanne, 1011, Switzerland
Related Publications (1)
Firmann M, Mayor V, Vidal PM, Bochud M, Pecoud A, Hayoz D, Paccaud F, Preisig M, Song KS, Yuan X, Danoff TM, Stirnadel HA, Waterworth D, Mooser V, Waeber G, Vollenweider P. The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord. 2008 Mar 17;8:6. doi: 10.1186/1471-2261-8-6.
PMID: 18366642BACKGROUND
Biospecimen
Urine, blood and DNA samples available, but not used in this study
Study Officials
- PRINCIPAL INVESTIGATOR
Peter Vollenweider, MD
Centre Hospitalier Universitaire Vaudois
- PRINCIPAL INVESTIGATOR
Gérard Waeber, MD, PhD
Centre Hospitalier Universitaire Vaudois
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate professor
Study Record Dates
First Submitted
August 14, 2017
First Posted
August 23, 2017
Study Start
July 1, 2017
Primary Completion
August 10, 2017
Study Completion
August 10, 2017
Last Updated
August 23, 2017
Record last verified: 2017-08
Data Sharing
- IPD Sharing
- Will not share