Reversing Muscle Loss With Exercise Training and Daily Consumption of Pomegranate Juice

NCT03258346 | Completed

• 1 other identifier: 2017-05-0092
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

A research study regarding the body's response to several weeks of training using short sprints and pomegranate juice supplementation

Conditions

Sarcopenia; Cardiovascular Risk Factor

Keywords

Pomegranate Juice; Functional Tasks of Living

Outcome Measures

Primary Outcomes (7)

• Change in muscle volume

  Volume of the thigh musculature as determined by MRI analysis.

  Baseline to 11 weeks

• Change in sarcopenia obesity

  Intermuscular adipose tissue infiltration as measured by MRI

  Baseline to 11 weeks

• Change in aerobic capacity

  VO2 Max on a cycle ergometer

  Baseline to 11 weeks

• Change in anaerobic capacity

  The percent of maximal aerobic capacity that a subject can exercise at while not building up blood lactate

  Baseline to 11 weeks

• Change in muscle fatigue

  Muscle aerobic stress as measured by near infrared spectroscopy

  Baseline to 11 weeks

• Change in body composition

  Fat and fat free regional and total mass as measured by dual x-ray absorptiometry

  Baseline to 11 weeks

• Change in maximal power production

  The ability to produce power as determined on the cycle ergometer and measured in watts

  Baseline to 11 weeks

Secondary Outcomes (6)

• Change in cardiovascular risk factors

  Baseline to 11 weeks

• Change in urolithins

  Baseline, 2 hrs after consuming first pomegranate or placebo supplement

• Change in Microbiome

  Baseline, week 10 and week 15

• Change in maximal isometric strength

  Baseline to 11 weeks

• Change in functional tests of living

  Baseline to 11 weeks

Study Arms (2)

Exercise and Pomegranate Juice

EXPERIMENTAL

Exercise training with daily consumption of pomegranate juice containing polyphenols

Other: Inertial Load Cycling Training; Dietary Supplement: Pomegranate Juice

Exercise and Placebo

PLACEBO COMPARATOR

Exercise training with daily consumption of pomegranate juice with polyphenols removed

Other: Inertial Load Cycling Training; Dietary Supplement: Placebo

Interventions

Inertial Load Cycling Training OTHER

Each session of training will require a total of 15 min with the total time actually exercising of only 60-120 sec. The first week will consist of performing 15 'sprints' on the ILE, beginning each sprint with 56 sec of rest. During week 2-5, subjects will rest 41 sec between sprints, completing 20 bouts. Finally, during weeks 6-10, subjects will take 26 s rest between sprints and complete 30 bouts).

Also known as: High intensity interval training

Exercise and Placebo; Exercise and Pomegranate Juice

Pomegranate Juice DIETARY_SUPPLEMENT

Subjects will consume 8oz of pomegranate juice daily for duration of study.

Exercise and Pomegranate Juice

Placebo DIETARY_SUPPLEMENT

Subjects will consume 8oz of pomegranate juice daily, that has had the polyphenols removed.

Exercise and Placebo

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• year old male and females

You may not qualify if:

• not currently exercising regularly
• meets criteria for MRI scanning at Imaging Research Center at UT Austin
• history of heart disease
• knee/hip joint problems

Sponsors & Collaborators

• University of Texas at Austin: lead
• POM Wonderful LLC: collaborator

Study Sites (1)

Human Performance Laboratory

Austin, Texas, 78712, United States

Location

Related Publications (1)

• Allen JR, Satiroglu R, Fico B, Tanaka H, Vardarli E, Luci JJ, Coyle EF. Inertial Load Power Cycling Training Increases Muscle Mass and Aerobic Power in Older Adults. Med Sci Sports Exerc. 2021 Jun 1;53(6):1188-1193. doi: 10.1249/MSS.0000000000002588.

  PMID: 33433149 DERIVED

MeSH Terms

Conditions

Sarcopenia

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Edward F Coyle, PhD

  UT Austin

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Pomegranate juice will be administered in double blind placebo controlled method. Coding will be established by POM Wonderful, LLC.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 12, 2017
• First Posted: August 23, 2017
• Study Start: November 7, 2017
• Primary Completion: December 15, 2018
• Study Completion: December 15, 2018
• Last Updated: February 20, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)