Application of Diffusion Tensor Imaging in Alzheimer's Disease :Quantification of White Matter Micro-structural Changes

NCT03255720 | Unknown DMC

• 1 other identifier: diffusion tensor imaging
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Diffusion Tensor imaging of white matter degeneration in Alzheimer disease

Conditions

Alzheimer Dementia

Outcome Measures

Primary Outcomes (1)

• the extent of tissue damage of several brain white matter regions in patients with Alzheimer's disease.

  provide a complete picture of the distribution of microstructural white matter damage in Alzheimer's disease

  4 years

Study Arms (2)

20 patients with Alzheimer disease

The study will be performed at the Radiodiagnosis department of assiut university hospital. Selection of 20 patients clinically and laboratory diagnosed as Alzheimer disease and another 20 people matched healthy controls who have no complaints of cognitive problems.

20 people matched healthy controls

health control people who have no complaints of cognitive problems.

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

old aged people over 60 years

You may qualify if:

• cognitive complaints with interference in complex occupational and social activities.
• changes in cognition reported by the patient ,informant or clinician.
• absence of profound sub-cortical ischemic changes.

You may not qualify if:

• state of delirium
• stroke event within 2 weeks
• appearance of cortical and /cortico-subcortical non -lacunar territorial infarcts and watershed infarcts ,hemorrhage ,signs of normal pressure hydrocephalus ,and specific causes of white matter lesions (e.g. multiple sclerosis, sarcoidosis, brain irradiation)
• derangements in serology tests contributing to cognitive impairment (e.g. abnormal levels of free T4 or rapid plasma reagin.
• severe hearing or visual impairment.
• cases of severe dementia.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 4 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: August 15, 2017
• First Posted: August 21, 2017
• Study Start: September 29, 2017
• Primary Completion: December 1, 2022
• Study Completion: December 31, 2022
• Last Updated: September 26, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will not share