Cardiac Blood Flow Patterns Associated With Left Ventricular Myocardial Damage

NCT03253835 | Enrolling By Invitation

• 1 other identifier: CMR-12-LHD
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Various factors affect the performance of the heart: The contractile properties of myocardial muscle cells are the fundamental devices for translating tension-generation and shortening of the cardiac muscle into pressure-generation and blood volume ejection from the heart into the body. On the other hand, the performance of heart can be analyzed with respect to input and output of blood to/from the hollow cardiac muscle and evaluated in terms of the performance of a pump: With every heartbeat blood is sucked from a low-pressure system (veins) and pumped to the arterial high-pressure system via one-way valves, whereas efficiency, ejected blood volume, blood flow and pressures are linked by hemodynamic laws. Cardiac magnetic resonance (CMR) is the "gold standard technique" to determine cardiac function and muscle mass, as well as for non-invasive diagnosis of myocardial necrosis/fibrosis. Furthermore, new CMR imaging techniques enabling the measurement of myocardial magnetic relaxation times for characterization of myocardial morphology and the acquisition of time-resolved, three-dimensional blood flow velocity fields in the heart and surrounding vessels, represent promising tools for the evaluation of the interaction between myocardial morphology and cardiac function. Aim of this explorative study is to 1. identify myocardial pathology-associated blood flow patterns in the heart and surrounding great vessels, and 2. correlate characteristic blood flow patterns in the heat (existence of vortices, vorticity, vortex formation, propagation dynamics …) with myocardial injuries.

Conditions

Cardiomyopathies; Myocardial Injury; Healthy

Outcome Measures

Primary Outcomes (1)

• Myocardial pathology-associated blood flow patterns in the heart and surrounding great vessels

  Morphologic, functional and blood flow CMR parameters will be evaluated with different techniques. Cardiac blood flow pattern parameters will be correlated with myocardial injury derived non-invasively from late gadolinium enhancement

  2 years

Study Arms (2)

Myocardial Injury

patients with myocardial injuries due to ischemic heart disease, patients with myocardial injuries due to non-ischemic heart disease.

Diagnostic Test: Single Group Assignment

No Myocardial Injury

subjects without myocardial injuries with normal cardiac function subjects without myocardial injuries with altered cardiac function

Diagnostic Test: Single Group Assignment

Interventions

Single Group Assignment DIAGNOSTIC_TEST

Myocardial Injury; No Myocardial Injury

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to CMR investigation. If suitable and inclusion criteria are met, the patient will be asked if she/he is interested in participating in this study. Participation means, that aside from the respective routine CMR protocol, additional images will be taken within the investigation resulting in 15-20 minutes extra investigation time.

You may qualify if:

• patients age 20-80 years,
• patients with and without ischemic or non-ischemic myocardial injuries scheduled for routine cardiac magnetic resonance imaging,
• ability to hold the breath,
• ability to give informed consent

You may not qualify if:

• patients with metal devices or other magnetic material in or on the subjects body which will be hazardous for magnetic resonance investigation (e.g. heart pace-maker, brain aneurysm clip, nerve stimulators, electrodes, penile implants, colored contact lenses, patch to deliver medications through the skin, any metal implants as rods, joints, plates, pins, screws, nails or clips, embolization coil, or any metal fragments or shrapnel in the body),
• patients with tendency toward claustrophobia,
• hemodynamically unstable patients,
• patients with (major) arrhythmia
• pregnancy,
• impaired kidney function indicated by creatin clearance lower than 60 ml/min (creatin clearance will be calculated according to Cockroft-Gault formula)

Sponsors & Collaborators

• Medical University of Graz: lead
• Anniversary Fund of the Oesterreichische Nationalbank: collaborator

Study Sites (1)

Medical Unitersity Graz, Department of Radiology, Division of General Radiology

Graz, Styria, 8036, Austria

Location

Related Publications (3)

• Krauter C, Reiter U, Reiter C, Nizhnikava V, Schmidt A, Stollberger R, Fuchsjager M, Reiter G. Impact of the Choice of Native T1 in Pixelwise Myocardial Blood Flow Quantification. J Magn Reson Imaging. 2021 Mar;53(3):755-765. doi: 10.1002/jmri.27375. Epub 2020 Oct 8.

  PMID: 33034120 RESULT

• Krauter C, Reiter U, Reiter C, Nizhnikava V, Masana M, Schmidt A, Fuchsjager M, Stollberger R, Reiter G. Automated mitral valve vortex ring extraction from 4D-flow MRI. Magn Reson Med. 2020 Dec;84(6):3396-3408. doi: 10.1002/mrm.28361. Epub 2020 Jun 18.

  PMID: 32557819 RESULT

• Reiter C, Reiter G, Krauter C, Kolesnik E, Greiser A, Scherr D, Schmidt A, Fuchsjager M, Reiter U. Impact of the evaluation method on 4D flow-derived diastolic transmitral and myocardial peak velocities: Comparison with echocardiography. Eur J Radiol. 2024 Jan;170:111247. doi: 10.1016/j.ejrad.2023.111247. Epub 2023 Dec 5.

  PMID: 38071909 RESULT

MeSH Terms

Conditions

Cardiomyopathies

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Michael Fuchsjäger, Univ.-Prof.

  Medical Universtiy of Graz

  STUDY CHAIR

• Ursula Reiter, PD DI Dr.

  Medical Universtiy of Graz

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PD DI Dr.

Study Record Dates

• First Submitted: August 16, 2017
• First Posted: August 18, 2017
• Study Start: November 21, 2013
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2027
• Last Updated: February 12, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)