Endothelial and Microvascular Functions in Patients With Myocardial Ischemia
Evaluation of Endothelial and Microvascular Functions in Patients With Myocardial Ischemia Detected by Scintilography and Normal Coronariography
1 other identifier
observational
50
0 countries
N/A
Brief Summary
Cardiovascular diseases (CVD) are responsible, throughout the world, for high mortality rates and cardiovascular morbidity. Endothelial dysfunction is the earliest marker of clinical atherosclerosis development. Human studies show that endothelial and microvascular dysfunction are independent predictors of ischemic cardiovascular events and long-term prognosis. The study´s objective is to evaluate the endothelial and peripheral microcirculation changes by venous occlusion plethysmography (VOP), nailfoldvideocapillaroscopy (NVC) and serum biomarkers in patients with myocardial ischemia detected by scintigraphy and normal coronarography.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2014
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 30, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 30, 2015
CompletedFirst Submitted
Initial submission to the registry
August 2, 2017
CompletedFirst Posted
Study publicly available on registry
August 9, 2017
CompletedAugust 9, 2017
August 1, 2017
1.5 years
August 2, 2017
August 4, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
%Hyper
Increment of forearm blood flow during reactive hyperemia after 5 minutes arm ischemia with venous occlusion plethysmography.
One year
Secondary Outcomes (16)
Intercellular adhesion molecule (ICAM)
One year
Vascular adhesion molecule (VCAM)
One year
Adiponectin
One year
Endothelin
One year
LDL-oxidized
One year
- +11 more secondary outcomes
Study Arms (2)
Ischemic patient - IP
25 participants with myocardial ischemia detected by scintigraphy and normal coronarography
Control group - CG
25 healthy non-ischemic individuals
Eligibility Criteria
Fifty patients were studied: 39% male and 61% female. The mean age was 48 ± 15.8 years, being: 56.5 ± 10.5 years in the IP group and 39.4 ± 15.8 years in the CG. The mean BMI was 26.5 ± 4.30 kg/m².
You may qualify if:
- The study population consisted of 50 patients of both sexes, stratified into two groups: patients with myocardial ischemia detected by scintigraphy (group IP, n = 25) and healthy individuals (CG group, n = 25). In the patients who underwent scintigraphy with tomographic sections and presented any type of image attenuation during the examination, they also underwent a complementary prone position technique. Patients without these characteristics scintigraphy methodologies were excluded from the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Rio de Janeiro State Universitylead
- Camillo L.C. Junqueiracollaborator
- Esmeralci Ferreiracollaborator
- Maria das Graças C. Souzacollaborator
- Eliete Bouskelacollaborator
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD and PHD
Study Record Dates
First Submitted
August 2, 2017
First Posted
August 9, 2017
Study Start
March 1, 2014
Primary Completion
August 30, 2015
Study Completion
August 30, 2015
Last Updated
August 9, 2017
Record last verified: 2017-08
Data Sharing
- IPD Sharing
- Will not share