NCT03240588

Brief Summary

The objective of the study is to characterize the relationship between select objective metrics and clinical outcomes in chronic pain patients treated with Boston Scientific commercially approved neurostimulation systems.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
544

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jul 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

16 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 11, 2017

Completed
20 days until next milestone

Study Start

First participant enrolled

July 31, 2017

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 7, 2017

Completed
6.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 8, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 8, 2024

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

May 8, 2025

Completed
Last Updated

May 8, 2025

Status Verified

May 1, 2025

Enrollment Period

6.6 years

First QC Date

July 11, 2017

Results QC Date

March 7, 2025

Last Update Submit

May 7, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Pain Responder Rate

    Proportion of subjects with 50% or greater reduction in Low Back pain

    12 months

Study Arms (3)

Boston Scientific Spinal Cord Stimulator (SCS) Systems (Day 0 Enrollment) ENVISION Study

EXPERIMENTAL

Patients enrolled in the ENVISION study. Follow-up period is based on date they signed the informed consent and were enrolled into the study. All commercially approved Boston Scientific neurostimulation systems indicated for the treatment of chronic pain, except for Precision™ and Precision™ Plus.

Device: Neurostimulation System

Boston Scientific Spinal Cord Stimulator (SCS) Systems (Day 0 SCS Trial Procedure) Navitas Study

EXPERIMENTAL

Patients enrolled in the NAVITAS study. Follow-up period is based on date of their SCS Trial Procedure. All commercially approved Boston Scientific neurostimulation systems indicated for the treatment of chronic pain.

Device: Neurostimulation System

Boston Scientific SCS Systems (Day 0 Implantable Pulse Generator (IPG) Activation) Navitas Study

EXPERIMENTAL

Patients enrolled in the NAVITAS study. Follow-up period is based on date of their Implantable Pulse Generator (IPG) was activated. All commercially approved Boston Scientific neurostimulation systems indicated for the treatment of chronic pain.

Device: Neurostimulation System

Interventions

Spinal cord stimulation

Boston Scientific SCS Systems (Day 0 Implantable Pulse Generator (IPG) Activation) Navitas StudyBoston Scientific Spinal Cord Stimulator (SCS) Systems (Day 0 Enrollment) ENVISION StudyBoston Scientific Spinal Cord Stimulator (SCS) Systems (Day 0 SCS Trial Procedure) Navitas Study

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \- Is willing and able to comply with completing protocol required assessments and evaluations

You may not qualify if:

  • \- Has any pain-related diagnosis, medical/psychological condition or external factors that, in the investigator's medical judgment, might confound reporting of study outcomes (e.g. history of pelvic pain, anginal pain, chronic migraine, involved in litigation, workmen's compensation)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (16)

Hope Research Institute

Phoenix, Arizona, 85018, United States

Location

Banner University Medical Center

Tucson, Arizona, 85724, United States

Location

Coastal Research Institute

Carlsbad, California, 92009, United States

Location

South Lake Pain Institute, Inc

Clermont, Florida, 34711, United States

Location

University of Florida Shands Hospital

Gainesville, Florida, 32608, United States

Location

Tallahassee Neurological Clinic, PA

Tallahassee, Florida, 32308, United States

Location

Ochsner Clinic Foundation

New Orleans, Louisiana, 70115, United States

Location

Willis-Knighton River Cities Clinical Research Center

Shreveport, Louisiana, 71105, United States

Location

Forest Health Medical Center

Ypsilanti, Michigan, 48198, United States

Location

KC Pain Centers

Lee's Summit, Missouri, 64086, United States

Location

The Center for Clinical Research, LLC

Winston-Salem, North Carolina, 27103, United States

Location

Pacific Sports and Spine, LLC

Eugene, Oregon, 97401, United States

Location

PCPMG Clinical Research Unit, LLC

Greenville, South Carolina, 29601, United States

Location

Precision Spine Care

Tyler, Texas, 75701, United States

Location

Washington Center for Pain Management

Bellevue, Washington, 98004, United States

Location

EvergreenHealth Pain Care

Kirkland, Washington, 98034, United States

Location

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Sr. Director, Clinical Operations
Organization
Boston Scientific Corporation

Study Officials

  • Natalie Bloom Lyons, M.S.

    Boston Scientific Neuromodulation Corporation

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 11, 2017

First Posted

August 7, 2017

Study Start

July 31, 2017

Primary Completion

March 8, 2024

Study Completion

March 8, 2024

Last Updated

May 8, 2025

Results First Posted

May 8, 2025

Record last verified: 2025-05

Locations