Assessment of DNA Damage Due to Ionizing Radiation
Assessment of DNA Damage and Capacity of DNA Repair System Among Nuclear Medicine and Clinical Oncology Workers Exposing to Ionizing Radiation
1 other identifier
observational
100
1 country
1
Brief Summary
detection of DNA damage due to occupational exposure to low dose ionizing radiation using comet assay technique and genotyping of certain DNA repair genes to detect inherited polymorphism.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jul 2016
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 20, 2016
CompletedFirst Submitted
Initial submission to the registry
August 2, 2017
CompletedFirst Posted
Study publicly available on registry
August 7, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2018
CompletedAugust 17, 2017
August 1, 2017
1.9 years
August 2, 2017
August 15, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
detection of DNA damage due to occupational exposure to ionizing radiation
comet assay technique will be used
6 month
Eligibility Criteria
Case control study that will include 100 participants (50 radiation exposed workers will be compared with 50 healthy age and sex-matched control group not exposed to radiation. G power program was used to calculate the sample size for two independent groups. power calculation estimated to detect an effect size of 0.88 of difference between means of two independent groups, with a p value \< 0.05 and 80% power,.
You may qualify if:
- The radiation exposed workers will include nurses, technicians and physicians.
- These persons will be occupationally exposed to different radiation sources.
You may not qualify if:
- History of diagnostic X-rays, radiotherapy and/or chemotherapy 12 months prior to sampling.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Assiut university
Asyut, 71511, Egypt
Study Officials
- PRINCIPAL INVESTIGATOR
asmaa HA mohamed, PHD
Assiut University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director, clinical research
Study Record Dates
First Submitted
August 2, 2017
First Posted
August 7, 2017
Study Start
July 20, 2016
Primary Completion
July 1, 2018
Study Completion
December 1, 2018
Last Updated
August 17, 2017
Record last verified: 2017-08