NCT03236480|Unknown
The Gut-lung Axis in Chronic Obstructive Pulmonary Disease
Dynamic Changes of the Respiratory Microbiota and Its Relationship to Fecal Microbiota in Chronic Obstructive Pulmonary Disease
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Dynamic Changes of the Respiratory Microbiota and Its Relationship to Fecal Microbiota in Chronic Obstructive Pulmonary Disease
Sponsor study identifier
Secondary identifiers
OTHER_GRANT · Ministery of science and technology of China
observational
100
1 country
1
Study Start
January 1, 2017
Actual (reported)Primary Completion
July 1, 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
January 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Patients with chronic obstructive pulmonary disease (COPD) are 2-3 times more likely to occur together with chronic gastrointestinal tract (GIT) diseases, such as inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS). Similarly, despite many patients have no history of acute or chronic respiratory disease, up to 50% of IBD patients and 33% of IBS patients have pulmonary involvement, such as inflammation or impaired lung function. Increasing evidence indicated chronic gut and lung disease share key conceptual features with the disorder and dysregulation of the microbial ecosystem. However, the underlying mechanisms are not well understood. Our study is aimed to elucidate the intimate relationship between the gastrointestinal tract and respiratory tract, and uncover the mechanisms by which the gut microbiota affects the immune responses in the lungs, and vice versa.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2017
Actual (reported)July 28, 2017
Actual (reported)August 2, 2017
Actual (reported)July 1, 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
January 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
all-cause mortality
all-cause death after the enrollment
patients will be followed for 3 months after their remission from hospital
exacerbations
during the 3-month follow-up
Patients who admitted to Peking Universtiy People's Hospital and Ningde City Hospital between January 2017 and January 2019 with AECOPD will be enrolled
People aged over 40, without any chronic respiratory disease or acute respiratory infections in the last 2 weeks, and be willing to participate in the study
Patients admitted to Peking University People's Hospital and Ningde City Hospital with an exacerbation of COPD between January 2017 and January 2019 will be enrolled.
Peking University People's Hospital
Beijing, Beijing Municipality, 100044, China
Xie Y, Xue Q, Jiao W, Wu J, Yu Y, Zhao L, Xu Y, Deng X, Fang G, Zheng Y, Gao Z. Associations Between Sputum Torque Teno Virus Load and Lung Function and Disease Severity in Patients With Chronic Obstructive Pulmonary Disease. Front Med (Lausanne). 2021 Apr 22;8:618757. doi: 10.3389/fmed.2021.618757. eCollection 2021.
1.Lower respiratory tract specimens including sputum, endotracheal aspiration and bronchoalveolar lavage fluid. 2.Peripheral whole blood samples 3.fecal samples
Zhancheng Gao, Pro.
Peking University People's Hospital
First Submitted
July 28, 2017
First Posted
August 2, 2017
Study Start
January 1, 2017
Actual (reported)Primary Completion
July 1, 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Quality Control for Chronic Obstructive Pulmonary Disease
Contact the study team to confirm eligibility.
Study Completion
January 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
August 2, 2017
Record last verified: 2017-07
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