Patient Registry of Posner-Schlossman Syndrome

NCT03233477 | Unknown

• 1 other identifier: IRB00006761-2014166
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly elevated intraocular pressure. Most of patients are the 20 to 50-year-old young adults, with unilateral eye involvement. PSS was originally deemed benign, but is now recognized as a relatively rare cause of chronic secondary glaucoma,especially in patients with recurrent episodes. This relatively rare disease is likely the result of the infections of a variety of organisms, and the bulk of literature supports the cytomegalovirus (CMV) as the leading cause. This study is an observational study that does not interfere with the normal clinical diagnosis and treatment process. The investigators in this study focus on observing the clinical symptoms and outcome of PSS, analyzing the factors that affect the prognosis of PSS, studying the association of its pathogenesis with the psychological status and the behavioral types of PSS patients; exploring the relationship between infection (CMV, HSV, Hp) and PSS; and studying the changes of local and systemic cytokine expression and its significance in patients with PSS.

Conditions

Posner Schlossman Syndrome

Keywords

Posner Schlossman Syndrome; cytokine expression; cytomegalovirus

Outcome Measures

Primary Outcomes (10)

• demographic characteristics

  age, sex, education level, systemic disease， mental state

  up to 10 years

• visual acuity

  uncorrected visual acuity and best corrected visual acuity

  up to 10 years

• intraocular pressure

  Goldmann

  up to 10 years

• slit-lamp examination

  anterior segment

  up to 10 years

• fundus photograph

  analysis the morphology of optic nerve head

  up to 10 years

• OCT

  zess

  up to 10 years

• visual field

  Humphrey visual field

  up to 10 years

• blood serum

  8ml

  up to 10 years

• aqueous humor

  0.2ml

  up to 10 years

• tissue

  iris and\& or trabecular meshwork tissue abandoned in the anti-glaucoma operation

  in the operation

Study Arms (3)

Posner-Schlossman Syndrome

Inclusion criteria： * Clinical diagnosis of Posner-Schlossman Syndrome * Able to communicate with doctor and understand this study Exclusion criteria: * Not be able to communicate with doctor and understand this study * One or more authorized investigators think he or she will suffer from any severe risks from the study

cataract

Inclusion criteria： * Clinical diagnosis of age-related cataract * Prepare for cataract operation * Open angle and intraocular pressure is normally at anytime * No family history of glaucoma Exclusion criteria: * Patients above 65 years old * With Secondary ocular hypertension * Have the history of receiving any ophthalmologic operation or anti-viral therapy * With diabetes mellitus * With autoimmune disease * Be receiving any therapy that can influence the virus-infection state and biochemical characteristics of serum and aqueous humor, or have received such therapy before one month

primary open-angle glaucoma

Inclusion criteria： * Both eyes involved * Open angle * Progressive glaucomatous optic neuropathy * Specific visual field loss of glaucoma * Intraocular pressure above the up limit of normal people Exclusion criteria: * Patients above 65 years old * With Secondary ocular hypertension * Have the history of receiving any ophthalmologic operation or anti-viral therapy * With diabetes mellitus * With autoimmune disease * Be receiving any therapy that can influence the virus-infection state and biochemical characteristics of serum and aqueous humor, or have received such therapy before one month

Eligibility Criteria

• Age: 12 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All the patients that visit the Peking University Third Hospital from July 2014 to July 2019 and are diognosed as Posner-Schlossman Syndrome, age-related cataract, or primary open-angle glaucoma.

You may qualify if:

• Volunteer to take part in this study and sign informed consent by oneself or the patient's legal representative
• Clinical diagnosis of Posner-Schlossman Syndrome, age-related cataract, or primary open-angle glaucoma
• Live in Beijing, China or being able to visit the Peking University Third Hospital every year after the beginning of the study or whenever the disease relapses

Sponsors & Collaborators

• Peking University: lead

Study Sites (1)

Peking University Third Hosipital

Beijing, Beijing Municipality, 100191, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

serum, aqueous humor，iris，trabecular meshwork

Study Officials

• Chun Zhang, PHD，MD

  Peking University Third Hospital

  STUDY DIRECTOR

Central Study Contacts

Shushan Li, MD

CONTACT

0086-135-5237-4266; shushan_li@yeah.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 22, 2017
• First Posted: July 28, 2017
• Study Start: July 31, 2014
• Primary Completion: July 31, 2024
• Study Completion: July 31, 2024
• Last Updated: October 14, 2020

Record last verified: 2020-10

Locations

CN (1)