Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
SunStar Project to Explore the Chronification Process in Headache Through Functional Imaging, Deep Phenotyping, and Analysis of CSF of Blood Products
1 other identifier
observational
700
1 country
1
Brief Summary
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal fluid, blood products, genetics, and patient phenotypes that might help explain this process.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2014
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 12, 2014
CompletedFirst Submitted
Initial submission to the registry
July 14, 2017
CompletedFirst Posted
Study publicly available on registry
July 27, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 15, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 1, 2026
July 23, 2025
December 1, 2024
11.7 years
July 14, 2017
July 18, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Prediction of chronification of headache
Brain Imaging, Phenotyping and Proteomics data will be combined to learn headache mechanisms.
five years
Study Arms (3)
Episodic Headache
Participants experiencing headache of any type more than twice per year but less than 15 days per month. No interventions
Chronic Headache
Participants experiencing headache more than 15 days per month for at least three consecutive months. No interventions
Control
Participants reporting fewer than two headaches per year. No interventions
Eligibility Criteria
Anybody above 18 years of age regardless of their race, gender will be able to participate in this study.
You may qualify if:
- Subjects must agree to sign informed consent.
- Subject must be able to or at least with some help willing to complete online questionnaires in English .
- Willing to comply with study instructions.
- must speak and understand English
You may not qualify if:
- \*Any neurological condition, at the discretion of the Principal Investigator (PI)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Stanford University School of Medicine
Stanford, California, 94304, United States
Related Publications (1)
Woldeamanuel YW, Sanjanwala BM, Cowan RP. Deep and unbiased proteomics, pathway enrichment analysis, and protein-protein interaction of biomarker signatures in migraine. Ther Adv Chronic Dis. 2024 Sep 18;15:20406223241274302. doi: 10.1177/20406223241274302. eCollection 2024.
PMID: 39314676DERIVED
Biospecimen
Cerebrospinal Fluid and Blood are collected and stored for analysis.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Robert Cowan, MD, FAAN
Stanford University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director and Chief, Division of Headache Medicine
Study Record Dates
First Submitted
July 14, 2017
First Posted
July 27, 2017
Study Start
December 12, 2014
Primary Completion (Estimated)
August 15, 2026
Study Completion (Estimated)
September 1, 2026
Last Updated
July 23, 2025
Record last verified: 2024-12
Data Sharing
- IPD Sharing
- Will not share