DNA Methylation and 1-C Metabolism Nutrient Intake
Dietary Intake of One-carbon Metabolism Nutrients and DNA Methylation in Peripheral Blood
1 other identifier
observational
5,983
0 countries
N/A
Brief Summary
The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays. The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2014
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2015
CompletedFirst Submitted
Initial submission to the registry
July 21, 2017
CompletedFirst Posted
Study publicly available on registry
July 24, 2017
CompletedJuly 24, 2017
July 1, 2017
2 years
July 21, 2017
July 21, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Blood DNA methylation
Methylation of DNA from peripheral blood, HumanMethylation 450 Beadchip assay
2014-2015
Secondary Outcomes (1)
Blood DNA methylation
2014-2015
Eligibility Criteria
The population is a sub-sample of the Melbourne Collaborative Cohort Study (MCCS), with non-random sampling based on selection into of six case-control studies nested within the MCCS. The MCCS is a prospective cohort study of 41,513 people (17,044 men and 24,469 women) recruited between 1990 and 1994. The age range at recruitment was 27-80 (99.3% being aged 40-69). Southern European migrants to Australia were over-sampled to extend the range of exposures, including dietary patterns. Participants in this sub-study had valid dietary intake data and valid measures of DNA methylation.
You may qualify if:
- Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study
- Completed a 121-item Food Frequency Questionnaire
- Had a blood DNA sample with a measure of methylation
You may not qualify if:
- Missing data in any of the outcome, exposure, or confounders (N=797 excluded)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Chamberlain JA, Dugue PA, Bassett JK, Hodge AM, Brinkman MT, Joo JE, Jung CH, Makalic E, Schmidt DF, Hopper JL, Buchanan DD, English DR, Southey MC, Giles GG, Milne RL. Dietary intake of one-carbon metabolism nutrients and DNA methylation in peripheral blood. Am J Clin Nutr. 2018 Sep 1;108(3):611-621. doi: 10.1093/ajcn/nqy119.
PMID: 30101351DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Graham G Giles, PhD
Cancer Council Victoria
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head, Cancer Epidemiology & Intelligence Division
Study Record Dates
First Submitted
July 21, 2017
First Posted
July 24, 2017
Study Start
January 1, 2014
Primary Completion
December 31, 2015
Study Completion
December 31, 2015
Last Updated
July 24, 2017
Record last verified: 2017-07