Effect of Magnesium Sulphate on the Intracranial Pressure of Preeclamptic Patients

NCT03210350 | Completed

• 1 other identifier: CH29011702
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

It had been shown that high percentage of severe preeclampsia patients got a high cerebral perfusion pressure (CPP) due to abnormal autoregulation of cerebral blood vessels with associated endothelial dysfunction and disrupted blood brain barrier. Moreover, patients with high CPP is more likely to present with headache compared to other patients with normal CPP.In this particular scenario, use of magnesium sulphate is associated with marked reduction of CPP and. hence prevention of cerebral damage.This hypothesis was confirmed by new magnetic resonance techniques that demonstrated brain edema in eclampsia/ severe preeclampsia patient mostly due to vasogenic edema and less commonly attributed to cytotoxic edema. Changes in the optic nerve sheath diameter (ONSD) mirrors the changes in the Intracranial pressure(ICP), subsequently when the intracranial pressure increases the optic nerve sheath diameter (ONDS) also increases. The aim of this study is to determine the effect Magnesium sulphate infusion on intracranial pressure, in patients presented with severe preeclampsia by measuring changes in the ONSD using ultrasound examination.

Conditions

Preeclampsia Severe

Outcome Measures

Primary Outcomes (1)

• Change in Optic nerve sheath diameter from baseline after magnesium Sulfate administration

  Change in Optic nerve sheath diameter from baseline at 1, 6 and 24 hours after completion of Magnesium sulfate loading dose

  1,6 and 24 hours

Interventions

Optic nerve sheath diameter DIAGNOSTIC_TEST

Optic nerve sheath diameter measurement using ultrasound

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

obstetric patients admitted to the HDU at Corniche Hospital for treatment of severe preeclampsia

You may qualify if:

• obstetric patients admitted to the HDU at Corniche Hospital for treatment of severe preeclampsia

You may not qualify if:

• (1) Patients undergone cranial or eye surgeries, (2) Patients with known intracranial pathology, (3) Patients suffering from glaucoma or any other eye pathology that prevent clear identification of the optic nerve, (4) Patients on drugs that may affect the cerebrospinal fluid

Sponsors & Collaborators

• Corniche Hospital: lead

Study Sites (1)

Corniche Hospital

Abu Dhabi, 3788, United Arab Emirates

Location

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 20, 2017
• First Posted: July 6, 2017
• Study Start: August 1, 2017
• Primary Completion: July 30, 2018
• Study Completion: September 30, 2018
• Last Updated: May 31, 2019

Record last verified: 2018-11

Data Sharing

• IPD Sharing: Will not share

Locations

AE (1)