Exercise Exposure Data Collection in Patients Undergoing Tumor Molecular Profiling

NCT03208374 | Active Not Recruiting

• 1 other identifier: 17-327
• Study Type: observational
• Target: 1,600
• Locations: 1 country
• Sites: 7

Brief Summary

This study will recruit approximately 5,000 patients with histologically confirmed cancer who have successfully completed MSK-IMPACT panel testing and collect information about tumor genetic results and patient exercise behavior history. The purpose of the study is to create a registry to collect exercise behavior history in patients who had IMPACT genetic panel testing on protocol IRB #12-245 "Genomic Profiling in Cancer Patients", IRB #06-107 "Storage and Research Use of Human Biospecimens," or IRB #09-141 "Collection of Human Biological Specimens from Patients for Research Studies." The investigators want to find a way to create an exercise database. This database will collect information about tumor genetic results and patient exercise behavior history.

Conditions

Cancer; Carcinoma

Keywords

Histologically confirmed cancer; IMPACT testing; 17-327

Outcome Measures

Primary Outcomes (1)

• Characterize exercise participant behavior history via exercise survey

  Participants who have undergone MSK-IMPACT panel testing will complete the exercise history survey. The 10 minute survey only asks participants about their exercise history, both in period before their most recent diagnosis as well as their current exercise behavior.

  Up to 5 years

Study Arms (1)

MSK-IMPACT genetic panel testing

Participants have completed MSK-IMPACT genetic panel testing on Memorial Sloan Kettering Cancer Center protocol IRB #12-245 and/or IRB #06-107 and/or IRB # 09-141 in the last 3 years.

Behavioral: Prior Exercise Behavior Questions - Harvard Health Professionals Exercise Questionnaire; Behavioral: Current Exercise Behavior Questions: International Physical Activity Questionnaire Short Form (IPAQ SF)

Interventions

Prior Exercise Behavior Questions - Harvard Health Professionals Exercise Questionnaire BEHAVIORAL

Participants will be asked how often on average over the year prior to their most recent diagnosis they participated in walking or hiking; jogging; running; calisthenics, aerobics, rowing, Nordic track; bicycling; tennis, squash, racquetball; lap swimming; weightlifting; and other aerobic exercise (e.g. heavy outdoor work), as well as their usual walking pace and flights of stairs climbed daily over the past 12 months prior to diagnosis.

MSK-IMPACT genetic panel testing

Current Exercise Behavior Questions: International Physical Activity Questionnaire Short Form (IPAQ SF) BEHAVIORAL

The purpose of this questionnaire is to provide common instruments that can be used to obtain internationally comparable data on exercise exposure in adults aged 15 to 80 years old.

Also known as: IPAQ SF

MSK-IMPACT genetic panel testing

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study cohort will consist of approximately 5,000 participants with histology confirmed cancer who have successfully completed MSK-IMPACT panel testing and are being treated at any Memorial Sloan Kettering Cancer Center site.

You may qualify if:

• Histologically-confirmed cancer.
• IMPACT testing with completed genomic profile completed within three years of initial recruitment approach
• Registered to Memorial Sloan Kettering Cancer Center protocol IRB# 12-245 and/or IRB #06-107 and/or IRB # 09-141
• ≥ 18 years of age
• ECOG Performance Status of 0 or 1

You may not qualify if:

• Unable to speak and read English
• Not willing to provide informed consent

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center: lead

Study Sites (7)

Memorial Sloan Kettering Basking Ridge (Consent only)

Basking Ridge, New Jersey, 07920, United States

Location

Memorial Sloan Kettering Monmouth (Consent only)

Middletown, New Jersey, 07748, United States

Location

Memorial Sloan Kettering Bergen (Consent only)

Montvale, New Jersey, 07645, United States

Location

Memorial Sloan Kettering Commack (Consent only)

Commack, New York, 11725, United States

Location

Memorial Sloan Kettering Westchester (Consent only)

Harrison, New York, 10604, United States

Location

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

Memorial Sloan Kettering Nassau (Consent only)

Uniondale, New York, 11553, United States

Location

Related Links

• Memorial Sloan Kettering Cancer Center

MeSH Terms

Conditions

Neoplasms; Carcinoma

Condition Hierarchy (Ancestors)

Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Study Officials

• Jessica Scott, PhD

  Memorial Sloan Kettering Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2017
• First Posted: July 5, 2017
• Study Start: June 27, 2017
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: July 4, 2025

Record last verified: 2025-07

Locations

US (7)