NCT03207477

Brief Summary

This study aim at following a cohort of prematurely born infants at 18 months corrected age, 4 and 7 years of age. This cohort had an evaluation of visual maturation at term equivalent age (TEA) with factors associated with impaired visual maturation. (PREMAVISION-CLinicalTrials.gov ID: NCT02890251). In this follow-up study, prematurely born infants vision will be compared to term born infants matched for postnatal age.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
37

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 30, 2017

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 2, 2017

Completed
5 months until next milestone

Study Start

First participant enrolled

November 20, 2017

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2020

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2021

Completed
Last Updated

August 13, 2021

Status Verified

August 1, 2021

Enrollment Period

2.6 years

First QC Date

June 30, 2017

Last Update Submit

August 9, 2021

Conditions

Keywords

InfantPrematurely bornmaturation

Outcome Measures

Primary Outcomes (3)

  • Visual acuity measurement

    Baby Vision Cards

    18 months corrected age

  • Visual acuity measurement

    Rossano Weiss test

    4 years post-natal age

  • Visual acuity measurement

    Parinaud and Snellen tests

    7 years post-natal age

Secondary Outcomes (3)

  • Measurement of cyclopegic refraction

    18 months corrected age

  • Measurement of cyclopegic refraction

    4 years of age

  • Measurement of cyclopegic refraction

    7 years of age

Study Arms (2)

Prematurely born infants

EXPERIMENTAL

Visual acuity measurement in prematurely born infants included in PREMAVISION study

Diagnostic Test: Visual acuity measurement

Term born infants

ACTIVE COMPARATOR

Visual acuity measurement in term born control infants

Diagnostic Test: Visual acuity measurement

Interventions

visual acuity measurement by Baby Vision cards at 18 months corrected age, by Rossano Weiss test at 4 years of age and optometric tests of Parinaud and Snellen at 7 years of age

Also known as: Measurement of cycloplegic refraction
Prematurely born infantsTerm born infants

Eligibility Criteria

Age18 Months - 7 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Infants included in the Premavision cohort
  • Term born healthy control infants at matched postnatal age

You may not qualify if:

  • Ocular malformation
  • Genetic abnormality
  • Neurodevelopmental impairment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Maternity Hospital CHRU

Nancy, 54035, France

Location

MeSH Terms

Conditions

Vision Disorders

Condition Hierarchy (Ancestors)

Sensation DisordersNeurologic ManifestationsNervous System DiseasesEye DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
PARALLEL
Model Details: Longitudinal cohort study with a control group
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 30, 2017

First Posted

July 2, 2017

Study Start

November 20, 2017

Primary Completion

June 30, 2020

Study Completion

June 30, 2021

Last Updated

August 13, 2021

Record last verified: 2021-08

Data Sharing

IPD Sharing
Will not share

Locations