Glucose Metabolism in Different PCOS Phenotypes
Associatons of PCOS Phenotypes With Ectopic Lipids, Adipocytokines and Parameters of Insulin Resistance
1 other identifier
observational
73
1 country
1
Brief Summary
In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2012
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 3, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 9, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
July 30, 2015
CompletedFirst Submitted
Initial submission to the registry
June 26, 2017
CompletedFirst Posted
Study publicly available on registry
July 2, 2017
CompletedJuly 2, 2017
June 1, 2017
2.6 years
June 26, 2017
June 27, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Comparison of glucose metabolism between PCOS women and healthy control subjects, using data of the OGTT.
In the present study the Glucose metabolism in PCOS women and control subjects was assessed with an OGTT. Therefore the dynamic levels of glucose, insulin and C-peptide were assessed during an extended OGTT for the calculation of Insulin resistance and beta-cell function. In addition an 1H-magnetic resonance spectroscopy was done for the assessment of the ectopic lipid content in the liver, heart and the skeletal muscle.
Up to 4 weeks
Study Arms (3)
PCOS-NIH
PCOS-Rotterdam
Controls
Interventions
For the assessment of glucose metabolism, including beta-cell function and insulin sensitivity an 75g-OGTT was conducted.
The amount of ectopic lipids in the liver, heart and the skeletal muscle was measured using 1H-magnetic resonance spectroscopy.
Eligibility Criteria
In the present study women with the Polycystic Ovary Syndrome, defined according to the NIH-criteria and the Rotterdam criteria were included. The control Group consisted of healthy volunteers without a diagnosis of prediabetes, Diabetes or the PCOS.
You may qualify if:
- Women with the polycystic ovary Syndrome defined according to the Rotterdam and the NIH-criteria
- healthy control subjects
You may not qualify if:
- BMI\>=40kg/m²
- Diagnosis of Diabetes in the PCOS-Group
- Diagnosis of Prediabetes or Diabetes in the control group
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Medical University of Vienna
Vienna, 1090, Austria
Related Publications (1)
Leutner M, Gobl C, Wolf P, Maruszczak K, Bozkurt L, Steinbrecher H, Just-Kukurova I, Ott J, Egarter C, Trattnig S, Kautzky-Willer A. Pericardial Fat Relates to Disturbances of Glucose Metabolism in Women with the Polycystic Ovary Syndrome, but Not in Healthy Control Subjects. Int J Endocrinol. 2018 Aug 7;2018:5406128. doi: 10.1155/2018/5406128. eCollection 2018.
PMID: 30158974DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Alexandra Kautzky-Willer, Univ.Prof.Dr.
Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Univ.Prof.Dr.
Study Record Dates
First Submitted
June 26, 2017
First Posted
July 2, 2017
Study Start
December 3, 2012
Primary Completion
July 9, 2015
Study Completion
July 30, 2015
Last Updated
July 2, 2017
Record last verified: 2017-06