Use of Biopsies of Abdominal Subcutaneous Fat to Study the Role of the Activation of Endocannabinoid 1 Receptors (CB1R) on Adipocyte Glucolipid Metabolism

NCT03202706 | Completed

• 1 other identifier: VERGES 2015
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is associated with hyperactivation of the endocannabinoid system, and its inhibition by the administration of CB1 receptor (CB1R) antagonists, leads to a decrease in food intake, weight loss and an improvement in metabolic parameters. Even though the reduction in food intake following central CB1R inactivation seems to be the principal cause of weight loss and the improvement in metabolic parameters, several studies in animals and humans have indicated that peripheral CB1R could also be implicated in the regulation of glucolipid metabolism. As a result, it has been suggested that the long-term beneficial effects of inactivation of the endocannabinoid system are due to both central effects on food intake and peripheral effects involving adipose tissue, the liver, skeletal muscle and the pancreas. It appears essential to determine the role of CB1R located in peripheral tissues and in particular in adipose tissue, which plays an active role in maintaining glucolipid homeostasis. The experiments conducted in this project consist in studying in biopsies of abdominal subcutaneous fat whether activation of adipocyte CB1R modifies adipocyte metabolism by determining the mechanisms. The investigators hypothesize that activation of CB1R in adipose tissue will lead to the stimulation of lipolysis dependent on the alteration of the insulin signal, and therefore that inactivation of the endocannabinoid system by blocking peripheral CB1R could constitute a therapeutic approach to improve obesity-related insulin resistance and dyslipidaemia.

Conditions

Hernia Surgery

Outcome Measures

Primary Outcomes (1)

• Glucolipid metabolism analysis in human abdominal subcutaneous and visceral fat

  Baseline

Study Arms (1)

Patients

Procedure: Samples of adipose tissue

Interventions

Samples of adipose tissue PROCEDURE

Samples of visceral and subcutaneous adipose tissue collected during hernia surgery

Patients

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients undergoing surgery for hernia

You may qualify if:

• men aged 18 to 70 years
• persons who have provided oral consent
• persons undergoing surgery for hernia

You may not qualify if:

• persons without health insurance cover
• BMI \> 30
• diabetes
• associated diseases: cancer, chronic inflammatory diseases
• adults under guardianship
• obese subjects
• men aged 18 to 70 years
• BMI \> 30
• persons who have provided oral consent
• persons undergoing surgery for hernia
• persons without health insurance cover
• diabetes
• associated diseases: cancer, chronic inflammatory diseases
• adults under guardianship
• diabetic obese subjects

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

CHU Dijon Bourgogne

Dijon, 21000, France

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 21, 2017
• First Posted: June 28, 2017
• Study Start: February 24, 2016
• Primary Completion: January 7, 2020
• Study Completion: January 7, 2020
• Last Updated: February 22, 2024

Record last verified: 2024-02

Locations

FR (1)