Clinical Subgroups in Patellofemoral Pain Syndrome

NCT03201133 | Completed

• 1 other identifier: UFRGS 1.978.838
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Patellofemoral pain syndrome (PFPS) is a multifactorial pathology characterized by diffuse retropatellar and peripatellar pain in the knee joint, exacerbated by overloading activities on the patellofemoral joint. However, this disease showed high degree of patients not responsive to therapeutic strategies. This condition occurred because several factors is related to disease such as: (1) proximal factors (involving trunk and hip), (2) local factors (surrounding and or within the patellofemoral joint) and (3) distal factors (involving ankle and foot). Thus, the identification of clinical subgroups based in anatomic changes (proximal, local and distal factors) is a recent strategy that could help in the therapeutic strategies focused on the etiology of the disease, improve responsiveness to treatment, clinical and functional benefits.

Conditions

Patellofemoral Pain Syndrome

Outcome Measures

Primary Outcomes (6)

• Muscular strength tests of hip and knee muscles.

  Isometric torque of knee extensor muscles, hip abductor, extension and medial rotation muscles through hand-held dynamometer tests will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  1 day

• Muscle thickness measures

  Muscle thickness (in millimeters) of vastus lateralis, vastus medialis and rectus femoris muscle. Muscle thickness of gluteus medius, maximus and peroneus muscle through ultrasound equipment. Tests Test will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  1 day

• Muscle activation of knee, hip and foot muscles

  Muscle activation measures of quadriceps, gluteus maximus, gluteus medius and peroneus muscles during unilateral squat through surface electromyography. Tests will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  1 day

• Kinematics during unilateral squat

  Pelvis, hip, knee and ankle angular displacement during unilateral squat through kinematics analysis. Tests will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  1 day

• Fascicle length measures

  Fascicle length (in milimeters) of vastus lateralis, vastus medialis and rectus femoris muscle through ultrasound equipment. Tests Test will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  1 day

• Pennation angle measures

  Pennation angle (in °) of vastus lateralis, vastus medialis and rectus femoris muscle through ultrasound equipment. Tests Test will be performed to create clinical subgroups after cluster analysis for a focused intervention in the second step.

  1 day

Study Arms (3)

Patellofemoral pain syndrome with changes in proximal factors

Diagnostic Test: Neuromuscular evaluation

Patellofemoral pain syndrome with changes in local factors

Diagnostic Test: Neuromuscular evaluation

Patellofemoral pain syndrome with changes in distal factors

Diagnostic Test: Neuromuscular evaluation

Interventions

Neuromuscular evaluation DIAGNOSTIC_TEST

(1) Muscle trunk endurance test; (2) Hip isometric strength (abductor, lateral rotation, extension); (3) Knee extensor isometric strength; (4) unilateral squat; (5) navicular drop test; (6) muscle architecture at rest of gluteus medius, gluteus maximus,vastus lateralis, vastus medialis and rectus femoris; (7) muscle activation during unilateral squat (gluteus and quadriceps muscles); (8) pennation angle of obliques vastus medialis; (9) medial patellofemoral ligament length; (10) knee pain.

Patellofemoral pain syndrome with changes in distal factors; Patellofemoral pain syndrome with changes in local factors; Patellofemoral pain syndrome with changes in proximal factors

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patellofemoral pain syndrome women

You may qualify if:

• Peripatellar or retropatellar pain in at least two of the following situations: squatting, running, kneeling, jumping, climbing or descending stairs and sitting for a prolonged period of time for at least three months.

You may not qualify if:

• Engaged in systematic exercise with focus on lower limb in the last six months and Had an injury to the hip and ankle joint in the last 12 months.

Sponsors & Collaborators

• Federal University of Rio Grande do Sul: lead

Study Sites (1)

Exercise Research Laboratory

Pôrto Alegre, Rio Grande do Sul, 90690200, Brazil

Location

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: June 21, 2017
• First Posted: June 28, 2017
• Study Start: September 1, 2017
• Primary Completion: October 25, 2017
• Study Completion: December 1, 2018
• Last Updated: April 18, 2019

Record last verified: 2019-04

Locations

BR (1)