Relationship of YWHAH Polymorphisms to Rheumatoid Arthritis Disease Severity
1 other identifier
observational
71
0 countries
N/A
Brief Summary
It is hypothesized that one or several of these 6 single nucleotide polymorphisms (SNPs) (rs2246704, rs2853884, rs3747158, rs4820059, rs7291050, and rs933226) in the YWHAH gene could be related to RA disease severity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2015
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2017
CompletedFirst Submitted
Initial submission to the registry
June 11, 2017
CompletedFirst Posted
Study publicly available on registry
June 19, 2017
CompletedJune 19, 2017
June 1, 2017
2 years
June 11, 2017
June 14, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Relationship to RA disease severity
The primary endpoint was the relationship of the six YWHAH SNPs to RA disease severity as based on the presence (1 point) or absence (0 points) across several domains: (A) serologic status (positive anti-CCP = 1 point, for example), (b) erosive changes (presence of erosions = 1 point), and (c) extra-articular manifestations (presence = 1 point).
2.5 years
Study Arms (2)
No SNP
Subjects have two copies of the wild type gene
SNP present
Subjects have one or two copies of the SNP
Interventions
Eligibility Criteria
RA patients at an academic medical center
You may qualify if:
- Have RA per 1987 or 2010 American College of Rheumatology Classification Criteria
You may not qualify if:
- None
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Thomas Shaak, PhD
Research Director
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 11, 2017
First Posted
June 19, 2017
Study Start
June 1, 2015
Primary Completion
June 1, 2017
Study Completion
June 1, 2017
Last Updated
June 19, 2017
Record last verified: 2017-06
Data Sharing
- IPD Sharing
- Will not share
Small pilot trial with limited data