Studies of Small DNA Virus Encoded Oncogenes in Viral Carcinogenesis Using Laboratory Model Systems

NCT03188315 | Unknown

• 1 other identifier: 17200086
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cancer is a devastating disease, presenting an immense disease burden to affected individuals and their families as well as health care systems with 10.9 million new cases and 6.7 million deaths per year. Approximately 12% of human cancers worldwide are caused by oncoviruses infection with more than 80% of cases occurring in the developing world. Tumor viruses can be classified into two groups based on their genetic material;

1. 1.DNA tumor viruses:
2. 2.Small DNA tumor viruses (Papilloma viruses, Polyoma viruses and adenoviruses).
3. 3.Complex DNA tumor viruses (Herpes viruses and Hepatitis B viruses).
4. 4.RNA tumor viruses ( Hepatitis C viruses and human T-cell leukemia virus "HTLV").

Conditions

DNA Virus Infections

Outcome Measures

Primary Outcomes (1)

• carcinogenesis

  developing cancer cervix

  6 months

Study Arms (2)

cases

EXPERIMENTAL

HPV detection HPV Genotyping HPV Oncogenes and oncoproteins

Genetic: HPV oncogenes

control

ACTIVE COMPARATOR

HPV detection HPV Genotyping HPV Oncogenes and oncoproteins

Genetic: HPV oncogenes

Interventions

HPV oncogenes GENETIC

PCR and oncogenes detection

cases; control

Eligibility Criteria

• Age: 18 Years - 65 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age: 18 - 65 years old.
• Women who are positive for HPV diagnosed by routine screening.
• Women willing to participate in the study and sign an informed consent

You may not qualify if:

• Age extremes (less than 18 years old or more than 65 years old).
• Immuno-comprised patients, patients under steroid therapy or chemotherapy, or patients with serious medical illness that could affect their immune system.
• Unknown medical history.

Sponsors & Collaborators

• Heba Momen kamel: lead

MeSH Terms

Conditions

DNA Virus Infections

Condition Hierarchy (Ancestors)

Virus Diseases; Infections

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: assistant lecturer

Study Record Dates

• First Submitted: June 13, 2017
• First Posted: June 15, 2017
• Study Start: September 1, 2017
• Primary Completion: February 28, 2018
• Study Completion: February 28, 2018
• Last Updated: June 15, 2017

Record last verified: 2017-06