Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis

NCT03183180 | Unknown

• 1 other identifier: 0137-16-ASMC
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

According to American Heart Association criteria, patients who have had Rheumatic Fever (RF) should be treated with antibiotic prophylaxis. Continuous prophylaxis is recommended in patients with well-documented histories of RF and in those with evidence of rheumatic heart disease. There is a limited data regarding adherence of patients to treatment and efficacy of treatment. In this study, patients with RF who are older than 21 years will be collected from a computerized database of 'Maccabi Healthcare Services', one of the biggest Israeli Health Funds. Patients will be assigned to the study after obtaining informed consent. Previous adherence to antibiotic prophylaxis will be examined according to computerized database of drugs which were issued to the patient since RF diagnosis. Past history of cardiac involvement, including past Echocardiograms, will be collected from computerized database. In addition, the current cardiac state will be assessed by an experienced cardiologist, including a full new Echocardiogram examination.

Conditions

Secondary Cardiac Damage in Rheumatic Fever

Outcome Measures

Primary Outcomes (1)

• Cardiac function including vulvar involvement

  Cardiac morphology and function measured by echocardiography

  60 days

Interventions

Echocardiogram DIAGNOSTIC_TEST

Current cardiac state will be assessed by an experienced cardiologist, including a full new Echocardiogram examination

Eligibility Criteria

• Age: 21 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients older than 21 years who were diagnosed with RF (before age 18 years) acoording to the computerized database.

You may qualify if:

• \- Patients older than 21 years who were diagnosed with RF (before age 18 years) according to the computerized database.

You may not qualify if:

• patients with other rheumatic disease diagnosed before RF diagnosis
• patients with other cardiac disease diagnosed before RF diagnosis
• patients with neoplastic disease diagnosed before RF diagnosis

Sponsors & Collaborators

• Assuta Hospital Systems: lead

MeSH Terms

Interventions

Echocardiography

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Director online centers

Study Record Dates

• First Submitted: June 7, 2017
• First Posted: June 9, 2017
• Study Start: June 1, 2017
• Primary Completion: December 1, 2017
• Study Completion: May 1, 2019
• Last Updated: June 9, 2017

Record last verified: 2017-06