Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans
The Effect of Concentrated Growth Factors in Regenerative Therapy in Furcation Involvements in Humans
1 other identifier
interventional
30
1 country
1
Brief Summary
Objective: To compare the effect of guided tissue regeneration (GTR) + concentrated growth factors (CGF) + bone graft and CGF + bone graft in the treat of II° furcations of human mandibular molars. Methods: At least thirty II°furcation involvements in mandibular molars will be included and randomly divided into two groups. The experimental group will accept GTR + CGF + bone graft therapy, and the control group will accept CGF + bone graft therapy. The clinical examination and cone beam computed tomography (CBCT) will be performed at baseline and 1 year post-surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2017
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2017
CompletedFirst Submitted
Initial submission to the registry
May 29, 2017
CompletedFirst Posted
Study publicly available on registry
June 8, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2020
CompletedJune 8, 2017
June 1, 2017
3 years
May 29, 2017
June 7, 2017
Conditions
Outcome Measures
Primary Outcomes (2)
clinical measurement
Probing depth
1 year
clinical parameter
clinical attachment loss
1 year
Secondary Outcomes (1)
radiographic parameter
1 year
Study Arms (2)
experimental
EXPERIMENTALGTR+CGF+bone graft, CGF
controlled
ACTIVE COMPARATORCGF+bone graft
Interventions
Guided tissue regeneration (GTR) combined with CGF and bone graft to treat mandibular furcation involvements
CGF combined with bone graft to treat mandibular furcation involvements
Eligibility Criteria
You may qualify if:
- II° furcation involvements in mandibular molars
- after periodontal therapy.
You may not qualify if:
- not healthy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Jing Qiaolead
Study Sites (1)
Peking university School and Hospital of Stomatology
Beijing, Beijing Municipality, 100081, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
yan zu zhang, doctor
dean
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
May 29, 2017
First Posted
June 8, 2017
Study Start
May 1, 2017
Primary Completion
May 1, 2020
Study Completion
July 1, 2020
Last Updated
June 8, 2017
Record last verified: 2017-06
Data Sharing
- IPD Sharing
- Will not share