The Association Between Herpes Simplex Viruses and Autism
1 other identifier
observational
80
0 countries
N/A
Brief Summary
Autism spectrum disorders are pervasive developmental disorders that include autistic disorder, Asperger's disorder, and pervasive developmental disorder-not otherwise specified.They are characterized by stereotypic behaviors, variable deficits in language and social skills and a wide range of other behavioral problems. Autism spectrum disorders manifest during childhood and at least thirty percent present with sudden clinical regression of development around three years of age.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2017
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 1, 2017
CompletedFirst Posted
Study publicly available on registry
June 8, 2017
CompletedStudy Start
First participant enrolled
August 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2019
CompletedJune 8, 2017
June 1, 2017
1 year
June 1, 2017
June 6, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
relationship between herpes simplex viruses infections and development of autism.
Detection of herpes simplex viruses antibody titre by sensitive enzyme linked immunosorbent assay and detection of herpes simplex viruses titre by quantitative polymerase chain reaction
12 month
Study Arms (2)
case group
Children suffering from Autism Spectrum disorders of variable grades attending to assiut University Children Hospital aged between six months and five years.
control group
Healthy children of matching age and sex.
Interventions
Blood samples will be collected and analyzed for herpes simplex viruses (type one and two) antibody by sensitive enzyme-linked immunosorbent assay and quantitative polymerase chain reaction.
Eligibility Criteria
Children suffering from Autism Spectrum disorders of variable grades attending to Assuit University Children Hospital and the same number of healthy children of matching age and sex as a control. Age between six months and five years
You may qualify if:
- Children suffering from Autism spectrum disorders.
- Age between six months and five years
You may not qualify if:
- Genetic disorders.
- History of metabolic or neurodegenerative disease.
- Gross motor delay.
- Audiologic problems.
- Mental retardation.
- Other psychiatric problems.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (11)
Johnson CP, Myers SM; American Academy of Pediatrics Council on Children With Disabilities. Identification and evaluation of children with autism spectrum disorders. Pediatrics. 2007 Nov;120(5):1183-215. doi: 10.1542/peds.2007-2361. Epub 2007 Oct 29.
PMID: 17967920BACKGROUNDZappella M. Autistic regression with and without EEG abnormalities followed by favourable outcome. Brain Dev. 2010 Oct;32(9):739-45. doi: 10.1016/j.braindev.2010.05.004. Epub 2010 Aug 12.
PMID: 20708360BACKGROUNDFombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res. 2009 Jun;65(6):591-8. doi: 10.1203/PDR.0b013e31819e7203.
PMID: 19218885BACKGROUNDLibbey JE, Sweeten TL, McMahon WM, Fujinami RS. Autistic disorder and viral infections. J Neurovirol. 2005 Feb;11(1):1-10. doi: 10.1080/13550280590900553.
PMID: 15804954BACKGROUNDDeLong GR, Bean SC, Brown FR 3rd. Acquired reversible autistic syndrome in acute encephalopathic illness in children. Arch Neurol. 1981 Mar;38(3):191-4. doi: 10.1001/archneur.1981.00510030085013.
PMID: 6162440BACKGROUNDGillberg C. Onset at age 14 of a typical autistic syndrome. A case report of a girl with herpes simplex encephalitis. J Autism Dev Disord. 1986 Sep;16(3):369-75. doi: 10.1007/BF01531665. No abstract available.
PMID: 3558293BACKGROUNDGhaziuddin M, Tsai LY, Eilers L, Ghaziuddin N. Brief report: autism and herpes simplex encephalitis. J Autism Dev Disord. 1992 Mar;22(1):107-13. doi: 10.1007/BF01046406. No abstract available.
PMID: 1592760BACKGROUNDHetzler BE, Griffin JL. Infantile autism and the temporal lobe of the brain. J Autism Dev Disord. 1981 Sep;11(3):317-30. doi: 10.1007/BF01531514.
PMID: 6189814BACKGROUNDDalod M, Salazar-Mather TP, Malmgaard L, Lewis C, Asselin-Paturel C, Briere F, Trinchieri G, Biron CA. Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J Exp Med. 2002 Feb 18;195(4):517-28. doi: 10.1084/jem.20011672.
PMID: 11854364BACKGROUNDSalazar-Mather TP, Hamilton TA, Biron CA. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J Clin Invest. 2000 Apr;105(7):985-93. doi: 10.1172/JCI9232.
PMID: 10749577BACKGROUNDLegaspi RC, Gatmaitan B, Bailey EJ, Lerner AM. Interferon in biopsy and autopsy specimens of brain. Its presence in herpes simplex virus encephalitis. Arch Neurol. 1980 Feb;37(2):76-9. doi: 10.1001/archneur.1980.00500510034004.
PMID: 7356411BACKGROUND
Biospecimen
quantitative polymerase chain reaction.
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principle investigator
Study Record Dates
First Submitted
June 1, 2017
First Posted
June 8, 2017
Study Start
August 1, 2017
Primary Completion
August 1, 2018
Study Completion
February 1, 2019
Last Updated
June 8, 2017
Record last verified: 2017-06
Data Sharing
- IPD Sharing
- Will not share