Influence of Deep Versus Moderate Neuromuscular Blockade During General Anesthesia on 30-day Readmission Rates

NCT03174223 | Completed

• 1 other identifier: p17.031
• Study Type: observational
• Target: 460
• Locations: 1 country
• Sites: 1

Brief Summary

Deep neuromuscular block (NMB) has shown to produce superior surgical conditions during various abdominal and non abdominal surgeries. It is however unknown if the application of deep NMB leads to favourable outcome, such as lower rate of postoperative complications in general and surgical infections in specific and ultimately lower readmission rates. In the leiden university medical center, deep NMB is routinely applied for a variety of procedures, most notably laparoscopic abdominal and retroperitoneal surgery, eye surgery and neuro radiologic intervention surgery, since 2014. This retrospective study intends to investigate whether the application of deep NMB for these procedures affects patient outcome and readmission rates.

Conditions

Postoperative Complications; Postoperative Wound Infection; Pneumonia

Outcome Measures

Primary Outcomes (1)

• Readmission

  readmission to the hospital

  30 days after surgery

Secondary Outcomes (1)

• Cost

  30 days after surgery

Study Arms (2)

Deep neuromuscular block

patients received a continuous rocuronium dose to maintain a depth of neuromuscular block of 1-2 twitches post tetanic count

Drug: deep neuromuscular block

moderate neuromuscular block

patients received neuromuscular block aimed at \> 0 twitches train of four

Interventions

deep neuromuscular block DRUG

a continuous dosing of rocuronium is used to achieve neuromuscular block of 1-2 twitches post tetanic count

Deep neuromuscular block

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients scheduled for laparoscopic abdominal surgery, eye surgery or neuro radiologic intervention surgery under general anesthesia

You may qualify if:

• deep neuromuscular block
• moderate neuromuscular block
• general anesthesia
• complete anesthesia chart

You may not qualify if:

• incomplete anesthesia chart
• missing data regarding postoperative complications or readmission

Sponsors & Collaborators

• Leiden University Medical Center: lead
• Merck Sharp & Dohme LLC: collaborator

Study Sites (1)

Leiden University Medical Center

Leiden, 2333ZA, Netherlands

Location

MeSH Terms

Conditions

Postoperative Complications; Surgical Wound Infection; Pneumonia

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Wound Infection; Infections; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: May 30, 2017
• First Posted: June 2, 2017
• Study Start: June 1, 2017
• Primary Completion: June 1, 2018
• Study Completion: July 1, 2018
• Last Updated: September 17, 2019

Record last verified: 2019-09

Locations

NL (1)